Disease · EFO_1001904

oral mucositis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. oral mucositis. Diseases, record EFO_1001904. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_1001904

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: oral mucositis; Open Targets
Open Targets ID: EFO_1001904; Open Targets
Other names: inflammation of mouth mucosa, inflammation of the mouth, mouth mucosa inflammation, mucositis oral, oral cavity mucosal damage, oral mucosa irritation, oral mucosal damage, oral mucosal injury, oral mucosal lesions, stomatitis; Open Targets
MeSH: D013280; MeSH
Highest stage of its drugs: Approval, for 1 of its 55 drugs, from DailyMed and TTD; Open Targets

Drugs55

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
PALIFERMIN	CHEMBL1201821	Protein	Approval	DailyMed and TTD	4	2	2	Drugs and targets
BENZYDAMINE HYDROCHLORIDE	CHEMBL1528134	Small molecule	Phase 3	ClinicalTrials.gov	5	5	5	Drugs and targets
CLOBETASOL PROPIONATE	CHEMBL1159650	Small molecule	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
DEXAMETHASONE	CHEMBL384467	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
REBAMIPIDE	CHEMBL1697771	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
SARGRAMOSTIM	CHEMBL1201670	Protein	Phase 3	ClinicalTrials.gov	2	2	1	Drugs and targets
DUSQUETIDE	CHEMBL3545314	Protein	Phase 3	ClinicalTrials.gov and TTD	2	1	1	Drugs and targets
DIPHENHYDRAMINE	CHEMBL657	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
GLUTAMINE	CHEMBL930	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
NYSTATIN	CHEMBL5465559		Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 55

See all 55 drugs

Targets44

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
CNR1	Cannabinoid receptor 1	2	Cannabinoid CB1 receptor agonist; Cannabinoid CB1 receptor negative allosteric modulator	Phase 1	https://conductscience.org/library/genes/1268	Drugs and targets
NR3C1	Glucocorticoid receptor	2	Glucocorticoid receptor agonist	Phase 3	https://conductscience.org/library/genes/2908	Drugs and targets
ADRA2A	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Phase 2	https://conductscience.org/library/genes/150	Drugs and targets
ADRA2B	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Phase 2	https://conductscience.org/library/genes/151	Drugs and targets
ADRA2C	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Phase 2	https://conductscience.org/library/genes/152	Drugs and targets
CRBN	CRL4(CRBN) E3 ubiquitin ligase	1	CRL4(CRBN) E3 ubiquitin ligase inhibitor	Phase 2	https://conductscience.org/library/genes/51185	Drugs and targets
CSF2RA	Granulocyte-macrophage colony-stimulating factor receptor	1	Granulocyte-macrophage colony-stimulating factor receptor agonist	Phase 3	https://conductscience.org/library/genes/1438	Drugs and targets
CSF2RB	Granulocyte-macrophage colony-stimulating factor receptor	1	Granulocyte-macrophage colony-stimulating factor receptor agonist	Phase 3	https://conductscience.org/library/genes/1439	Drugs and targets
CSF3R	Granulocyte colony-stimulating factor receptor	1	Granulocyte colony stimulating factor receptor agonist	Phase 2	https://conductscience.org/library/genes/1441	Drugs and targets
CUL4A	CRL4(CRBN) E3 ubiquitin ligase	1	CRL4(CRBN) E3 ubiquitin ligase inhibitor	Phase 2	https://conductscience.org/library/genes/8451	Drugs and targets

1 to 10 of 44

See all 44 targets

Trials47

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 2 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT03237325	DOM-INNATE: Study of SGX942 for the Treatment of Oral Mucositis in Patients With Concomitant Chemoradiation Therapy for Head and Neck Cancer	Phase 3	266	2022-08-29	Squamous Cell Carcinoma of the Oral Cavity and Oropharynx, Oral Mucositis	DUSQUETIDE	Its record names the disease	ClinicalTrials.gov
NCT01385748	Efficacy and Safety Study of Clonidine Lauriad® to Treat Oral Mucositis	Phase 2	183	2017-08-09	Oral Mucositis	CLONIDINE	Its record names the disease	ClinicalTrials.gov
NCT00293462	GM-CSF Mouthwash for Preventing and Treating Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer	Phase 3	91	2013-05-16	Head and Neck Cancer, Mucositis Oral, Radiation Toxicity, Tongue Cancer	SARGRAMOSTIM	Its record names the disease	ClinicalTrials.gov
NCT00385515	Efficacy of SNX-1012 in the Treatment of Oral Mucositis	Phase 2	81	2009-03-18	Stomatitis, Oral Mucositis	MECLOCYCLINE SULFOSALICYLATE	Its record names the disease	ClinicalTrials.gov
NCT01952847	Randomized Trial of Glutamine in Patients With Mucositis or Esophagitis	Phase 3	77	2022-06-15	Advanced Cancers	GLUTAMINE	Its record names the disease	ClinicalTrials.gov
NCT00109031	Palifermin for the Reduction of Oral Mucositis in Single-dose Evaluation (PROMISE)	Phase 3	47	2014-09-15	Cancer, Lymphoma, Leukemia	PALIFERMIN	Its record names the disease	ClinicalTrials.gov
NCT00031551	Evaluation of Efficacy and Mechanisms of an Antiinflammatory Intervention for Chemotherapy Related Mucosal Injury	Phase 2	27	2015-12-30	Stomatitis	ETANERCEPT	Its record names the disease	ClinicalTrials.gov
NCT03602066	Study Evaluating The Role of ClO2 on Mucositis for Pt. Undergoing Head/Neck Radiotherapy	Phase 2	14	2024-03-20	Head and Neck Carcinoma	CHLORINE DIOXIDE	Its record names the disease	ClinicalTrials.gov
NCT00075023	Effectiveness of Topical Thalidomide to Treat Chronic Graft-Versus-Host-Disease Related Stomatitis	Phase 2	10	2015-11-04	Graft-versus-Host Disease, Stomatitis	THALIDOMIDE	Its record names the disease	ClinicalTrials.gov
NCT02300727	Study to See How Safe Curcumin is and How Well it Works When Used to Treat Mucositis in Patients Getting Chemotherapy	Phase 1/2	6	2019-05-31	Mucositis	CURCUMIN	Its record names the disease	ClinicalTrials.gov

1 to 10 of 47

See all 47 trials

Comparisons in its trials10

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
SGX942 vs Placebo: deaths from any cause	7 of 127	9 of 139	266	NCT03237325	Trial comparisons
SGX942 vs Placebo: serious adverse events	74 of 127	64 of 139	266	NCT03237325	Trial comparisons
Arm I: GM-CSF Group (GG) vs Arm II: Salt & Soda Group (SS): Comparison of Number of Participants With Grade 1 or 2 Oral Mucositis (GM-CSF and SS Groups Only)	28 of 28	46 of 53	81	NCT00293462	Trial comparisons
SNX-1012 vs Placebo: Number of Participants With Ulcerative Oral Mucositis	22 of 44	11 of 21	65	NCT00385515	Trial comparisons
Radiation Therapy to Esophagus Patient Group - Glutamine vs Radiation Therapy to Esophagus Patient Group - Placebo: Number of Participants With Cancer Treatment Interruptions Due to Esophagitis	0 of 19	0 of 19	38	NCT01952847	Trial comparisons
Arm I (Chlorine Dioxide Sterilization) vs Arm II (Placebo): Incidence of Severe Oral Mucositis (OM) (>= World Health Organization [WHO] Mucositis Scale Grade 3)	0 of 6	0 of 8	14	NCT03602066	Trial comparisons
Arm I (Chlorine Dioxide Sterilization) vs Arm II (Placebo): deaths from any cause	0 of 6	0 of 8	14	NCT03602066	Trial comparisons
Arm I (Chlorine Dioxide Sterilization) vs Arm II (Placebo): serious adverse events	0 of 6	1 of 8	14	NCT03602066	Trial comparisons
mTOR Inhibitor Patient Group - Glutamine vs mTOR Inhibitor Patient Group - Placebo: Number of Participants With Cancer Treatment Interruptions Due to Mucositis	0 of 7	0 of 6	13	NCT01952847	Trial comparisons
Arm I (Chlorine Dioxide Sterilization) vs Arm II (Placebo): Rates of Radiotherapy Interruption	0 of 6	0 of 5	11	NCT03602066	Trial comparisons

Papers from its trials11

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
33290635	RESULT	1	PubMed
32920135	RESULT	1	PubMed
32062592	RESULT	1	PubMed
18164921	RESULT	1	PubMed
9145556	RESULT	1	PubMed
41862922	DERIVED	1	PubMed
40197962	DERIVED	1	PubMed
39711194	DERIVED	1	PubMed
38824583	DERIVED	1	PubMed
33580845	DERIVED	1	PubMed

1 to 10 of 11

See all 11 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_1001904

GET https://conductscience.org/api/diseases/v1/EFO_1001904/drugs?page=2

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