Disease · HP_0002315

Headache

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. Headache. Diseases, record HP_0002315. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0002315

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: Headache
Open Targets ID: HP_0002315
Other names: Headaches
Highest stage of its drugs: Approval, for 25 of its 82 drugs, from DailyMed and TTD

Source Open Targets

Drugs82

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
ACETAMINOPHEN	CHEMBL112	Small molecule	Approval	DailyMed	113	5	5	Drugs and targets
IBUPROFEN	CHEMBL521	Small molecule	Approval	DailyMed	15	5	5	Drugs and targets
CAFFEINE	CHEMBL113	Small molecule	Approval	DailyMed	5	2	2	Drugs and targets
ASPIRIN	CHEMBL25	Small molecule	Approval	DailyMed	17	1	1	Drugs and targets
DEXTROMETHORPHAN HYDROBROMIDE	CHEMBL1256818	Small molecule	Approval	DailyMed	70	0	0	Drugs and targets
PHENYLEPHRINE HYDROCHLORIDE	CHEMBL1200339	Small molecule	Approval	DailyMed	60	0	0	Drugs and targets
GUAIFENESIN	CHEMBL980	Small molecule	Approval	DailyMed	35	0	0	Drugs and targets
DIPHENHYDRAMINE HYDROCHLORIDE	CHEMBL1620	Small molecule	Approval	DailyMed	19	0	0	Drugs and targets
CHLORPHENIRAMINE MALEATE	CHEMBL1659	Small molecule	Approval	DailyMed	11	0	0	Drugs and targets
TRIPROLIDINE HYDROCHLORIDE	CHEMBL3188034	Small molecule	Approval	DailyMed	6	0	0	Drugs and targets

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Targets114

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
PTGS2	Cyclooxygenase	10	Cyclooxygenase inhibitor; Cyclooxygenase-2 inhibitor	Approval	https://conductscience.org/library/genes/5743	Drugs and targets
PTGS1	Cyclooxygenase	9	Cyclooxygenase inhibitor	Approval	https://conductscience.org/library/genes/5742	Drugs and targets
HRH1	Histamine H1 receptor	7	Histamine H1 receptor antagonist	Approval	https://conductscience.org/library/genes/3269	Drugs and targets
ADRA1A	Adrenergic receptor alpha	5	Adrenergic receptor alpha agonist; Adrenergic receptor alpha-1 agonist; Adrenergic receptor alpha-1 antagonist	Approval	https://conductscience.org/library/genes/148	Drugs and targets
ADRA1B	Adrenergic receptor alpha	5	Adrenergic receptor alpha agonist; Adrenergic receptor alpha-1 agonist; Adrenergic receptor alpha-1 antagonist	Approval	https://conductscience.org/library/genes/147	Drugs and targets
ADRA1D	Adrenergic receptor alpha	5	Adrenergic receptor alpha agonist; Adrenergic receptor alpha-1 agonist; Adrenergic receptor alpha-1 antagonist	Approval	https://conductscience.org/library/genes/146	Drugs and targets
SCN4A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6329	Drugs and targets
ADRA2A	Adrenergic receptor alpha	3	Adrenergic receptor alpha agonist; Adrenergic receptor alpha-2 agonist	Approval	https://conductscience.org/library/genes/150	Drugs and targets
ADRA2B	Adrenergic receptor alpha	3	Adrenergic receptor alpha agonist; Adrenergic receptor alpha-2 agonist	Approval	https://conductscience.org/library/genes/151	Drugs and targets
ADRA2C	Adrenergic receptor alpha	3	Adrenergic receptor alpha agonist; Adrenergic receptor alpha-2 agonist	Approval	https://conductscience.org/library/genes/152	Drugs and targets

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Trials61

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 5 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00754065	To Compare SH T00658ID Over Ortho Tri-Cyclen Lo (US/Canada)	Phase 3	409	2012-08-28	Contraception	DIENOGEST, ESTRADIOL VALERATE	Its record names the disease	ClinicalTrials.gov
NCT03441269	Adult Oral Ibuprofen Study for ED Pain Patients	Phase 4	225	2020-06-04	Pain, Acute	IBUPROFEN	Its record names the disease	ClinicalTrials.gov
NCT03220958	Metoclopramide for Post Traumatic Headache	Phase 3	160	2021-11-09	Post-Traumatic Headache	DIPHENHYDRAMINE, METOCLOPRAMIDE	Its record names the disease	ClinicalTrials.gov
NCT05967442	Magnesium Versus Prochlorperazine Versus Metoclopramide for Migraines	Phase 3	157	2024-10-01	Migraine, Headache	MAGNESIUM SULFATE, MAGNESIUM SULFATE ANHYDROUS, METOCLOPRAMIDE, PROCHLORPERAZINE	Its record names the disease	ClinicalTrials.gov
NCT00680823	Study of Intramuscular Ropivacaine Injections for Treatment of Pediatric Headache	Not applicable	150	2017-12-13	Headache, Migraine	ROPIVACAINE	Its record names the disease	ClinicalTrials.gov
NCT01048502	Fenofibrate and Omega-3 Fatty Acid Modulation of Endotoxemia	Not applicable	100	2016-02-19	Cardiovascular Disease	FENOFIBRATE, OMEGA-3 FATTY ACIDS	Its record names the disease	ClinicalTrials.gov
NCT00856232	Oxygen Therapy for the Treatment of Undifferentiated Headache in the Emergency Department	Not applicable	91	2013-05-03	Headache	AIR, MEDICAL, OXYGEN	Its record names the disease	ClinicalTrials.gov
NCT02266329	Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin	Phase 1/2	89	2024-06-26	Posttraumatic Headache, Combat Disorders, Post Concussion Syndrome, Headache, Mild Traumatic Brain Injury, Posttraumatic Migraine	PRAZOSIN HYDROCHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT02268058	Use of Ibuprofen and Acetaminophen for Treatment of Acute Headache Post Concussion in Children	Not applicable	80	2016-10-20	Concussion, Headache	ACETAMINOPHEN, IBUPROFEN	Its record names the disease	ClinicalTrials.gov
NCT02295280	A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective.	Not applicable	70	2018-04-02	Headache	CODEINE, DIPHENHYDRAMINE, METOCLOPRAMIDE	Its record names the disease	ClinicalTrials.gov

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Comparisons in its trials32

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Estradiol Valerate, Dienogest (Natazia, Qlaira, BAY86-5027) vs Ortho Tri-Cyclen Lo: serious adverse events	2 of 191	5 of 204	395	NCT00754065	Trial comparisons
Metoclopramide vs Placebo: deaths from any cause	0 of 81	0 of 79	160	NCT03220958	Trial comparisons
Metoclopramide vs Placebo: serious adverse events	0 of 81	0 of 79	160	NCT03220958	Trial comparisons
Metoclopramide vs Placebo: Sustained Headache Relief	24 of 78	18 of 76	154	NCT03220958	Trial comparisons
Prazosin vs Placebo: deaths from any cause	0 of 59	0 of 30	89	NCT02266329	Trial comparisons
Prazosin vs Placebo: serious adverse events	1 of 59	1 of 30	89	NCT02266329	Trial comparisons
Metoclopramide & Diphenhydramine vs Codeine: deaths from any cause	0 of 35	0 of 35	70	NCT02295280	Trial comparisons
Metoclopramide & Diphenhydramine vs Codeine: serious adverse events	0 of 35	0 of 35	70	NCT02295280	Trial comparisons
Metoclopramide IV & Diphenhydramine IV vs Codeine: Number of Participants With Adequate Relief of Headache as a Measure of Efficacy	34 of 34	32 of 32	66	NCT02295280	Trial comparisons
Treatment vs Standard Care: Incidence of Immediate and Post-discharge Complications.	2 of 12	1 of 11	23	NCT01785459	Trial comparisons

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Papers from its trials58

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
39801092	RESULT	1	PubMed
32583883	RESULT	1	PubMed
31694924	RESULT	1	PubMed
30877613	RESULT	1	PubMed
30612462	RESULT	1	PubMed
30152015	RESULT	1	PubMed
30054011	RESULT	1	PubMed
29285576	RESULT	1	PubMed
26926875	RESULT	1	PubMed
26830816	RESULT	1	PubMed

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0002315

GET https://conductscience.org/api/diseases/v1/HP_0002315/drugs?page=2

API reference For AI assistants