Disease · HP_0004755

Supraventricular tachycardia

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. Supraventricular tachycardia. Diseases, record HP_0004755. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0004755

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: Supraventricular tachycardia
Open Targets ID: HP_0004755
Other names: SVT, Supraventricular tachyarrhythmia
Highest stage of its drugs: Approval, for 1 of its 14 drugs, from FDA

Source Open Targets

Drugs14

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
LANDIOLOL HYDROCHLORIDE	CHEMBL2362410	Small molecule	Approval	FDA	2	0	0	Drugs and targets
ADENOSINE	CHEMBL477	Small molecule	Phase 3	ClinicalTrials.gov	5	5	5	Drugs and targets
DIGOXIN	CHEMBL1751	Small molecule	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
FLECAINIDE	CHEMBL652	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
PROPRANOLOL	CHEMBL27	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
SOTALOL	CHEMBL471	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
AMIODARONE	CHEMBL633	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
RANOLAZINE	CHEMBL1404	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
DEXMEDETOMIDINE	CHEMBL778	Small molecule	Unknown	ClinicalTrials.gov	2	2	2	Drugs and targets
DILTIAZEM	CHEMBL23	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 14

See all 14 drugs

Targets48

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
ADRB1	Beta-1 adrenergic receptor	4	Beta-1 adrenergic receptor antagonist	Approval	https://conductscience.org/library/genes/153	Drugs and targets
SCN5A	Sodium channel alpha subunit	3	Sodium channel alpha subunit blocker; Sodium channel protein type V alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6331	Drugs and targets
ADRB2	Beta-2 adrenergic receptor	2	Beta-2 adrenergic receptor antagonist	Phase 3	https://conductscience.org/library/genes/154	Drugs and targets
CACNA1C	Voltage-gated L-type calcium channel	2	Voltage-gated L-type calcium channel blocker	Unknown	https://conductscience.org/library/genes/775	Drugs and targets
CACNA1D	Voltage-gated L-type calcium channel	2	Voltage-gated L-type calcium channel blocker	Unknown	https://conductscience.org/library/genes/776	Drugs and targets
CACNA1F	Voltage-gated L-type calcium channel	2	Voltage-gated L-type calcium channel blocker	Unknown	https://conductscience.org/library/genes/778	Drugs and targets
CACNA1S	Voltage-gated L-type calcium channel	2	Voltage-gated L-type calcium channel blocker	Unknown	https://conductscience.org/library/genes/779	Drugs and targets
KCNH2	Voltage-gated inwardly rectifying potassium channel KCNH2	2	HERG blocker	Phase 3	https://conductscience.org/library/genes/3757	Drugs and targets
SCN4A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6329	Drugs and targets
ADORA1	Adenosine receptor	1	Adenosine receptor agonist	Phase 3	https://conductscience.org/library/genes/134	Drugs and targets

1 to 10 of 48

See all 48 targets

Trials10

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00390546	Multicenter Study of Antiarrhythmic Medications for Treatment of Infants With Supraventricular Tachycardia	Phase 3	72	2013-08-22	Supraventricular Tachycardia	DIGOXIN, PROPRANOLOL	Its record names the disease	ClinicalTrials.gov
NCT04392362	A Trial to Compare American Heart Association (AHA) and Simple (SIM)Method to Give Adenosine to Treat Supra-ventricular Tachycardia (SVT)	Phase 3	30	2021-06-25	Supra-ventricular Tachycardia	ADENOSINE	Its record names the disease	ClinicalTrials.gov
NCT01495481	Dexmedetomidine and Adenosine: Therapeutic Use for SVT	Not applicable	22	2017-03-28	Supraventricular Tachycardia	ADENOSINE, DEXMEDETOMIDINE	Its record names the disease	ClinicalTrials.gov
NCT02360397	Ranolazine Mediated PVC Reduction in Ischemic Heart Disease	Phase 2	6	2020-01-29	Ventricular Premature Complexes, Myocardial Ischemia	RANOLAZINE	Its record names the disease	ClinicalTrials.gov
NCT04203368	Adenosine Versus Verapamil for Management of Supraventricular Tachycardia Post- Coronary Artery Bypass Grafting	Not applicable	268		Supraventricular Tachycardia	ADENOSINE, VERAPAMIL	Its record names the disease	ClinicalTrials.gov
NCT02624765	Prospective Randomized Clinical Trial of Fetal Atrial Flutter & Supraventricular Tachycardia Therapy (FAST RCT)	Phase 3	105		Fetal Atrial Flutter Without Hydrops, Fetal Supraventricular Tachycardia Without Hydrops, Fetal Supraventricular Tachycardia With Hydrops	DIGOXIN, FLECAINIDE, SOTALOL	Its record names the disease	ClinicalTrials.gov
NCT07086560	PERceptions of Diltiazem Versus ADEnosine for Treatment of Supraventricular Tachycardia in the Emergency Department		100		Supraventricular Tachycardia (SVT)	ADENOSINE, DILTIAZEM	Its record names the disease	ClinicalTrials.gov
NCT04284150	Treatment of Supraventricular Tachycardia in Patients With Non-cardiac Surgery by Dexmedetomidine	Not applicable	60		Perioperative Period	DEXMEDETOMIDINE, MIDAZOLAM	Its record names the disease	ClinicalTrials.gov
NCT03528616	Management of Supraventricular Tachycardia of Children		50		Supraventricular Tachycardia	ADENOSINE, AMIODARONE, DIGOXIN, FLECAINIDE, PROCAINAMIDE, PROPRANOLOL	Its record names the disease	ClinicalTrials.gov
NCT03153072	Evaluation of the Pharmacokinetic Profile, Pharmacodynamic Effects, Acceptability and Tolerability of an Oral Amiodarone Solution of 15 mg / mL in Children With Supra Ventricular Tachycardia	Phase 2	0		Supraventricular Tachycardia	AMIODARONE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials11

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Digoxin vs Propranolol: Number of Treated Patients Experiencing First SVT Recurrence	6 of 32	12 of 39	71	NCT00390546	Trial comparisons
Digoxin vs Propranolol: Incidence of Adverse Outcomes in Infants With Propranolol or Digoxin	0 of 32	0 of 39	71	NCT00390546	Trial comparisons
Digoxin vs Propranolol: serious adverse events	0 of 27	0 of 34	61	NCT00390546	Trial comparisons
Dexmedetomidine vs Adenosine: Number of Participants With Sinus Pause >2.5 Sec After Termination of SVT	0 of 22	16 of 22	44	NCT01495481	Trial comparisons
Dexmedetomidine vs Adenosine: Number of Participants With Hypotension by Non-invasive Cuff in First 10 Minutes After Medication Administration	1 of 22	0 of 22	44	NCT01495481	Trial comparisons
Dexmedetomidine vs Adenosine: Number of Participants With Tachyarrhythmias After Medication Administration	0 of 22	0 of 22	44	NCT01495481	Trial comparisons
Dexmedetomidine vs Adenosine: Termination of SVT	16 of 22	21 of 22	44	NCT01495481	Trial comparisons
Dexmedetomidine vs Adenosine: serious adverse events	0 of 22	0 of 22	44	NCT01495481	Trial comparisons
Intervention Group vs Control Group: The Number of Patients With First Dose Successful Termination of the Supraventricular Tachycardia to a Sinus Rhythm of Less Than 140 With the AHA Versus a Simplified Method of Adenosine Administration	13 of 23	4 of 7	30	NCT04392362	Trial comparisons
Intervention Group vs Control Group: deaths from any cause	0 of 23	0 of 7	30	NCT04392362	Trial comparisons

1 to 10 of 11

See all 11 comparisons in its trials

Papers from its trials8

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
31671483	RESULT	1	PubMed
31168973	RESULT	1	PubMed
30170229	RESULT	1	PubMed
29025197	RESULT	1	PubMed
27654700	RESULT	1	PubMed
22613357	RESULT	1	PubMed
9426034	RESULT	1	PubMed
22962431	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0004755

GET https://conductscience.org/api/diseases/v1/HP_0004755/targets?page=2

API reference For AI assistants