Disease · HP_0011868
Sciatica
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. Sciatica. Diseases, record HP_0011868. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0011868
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Name
- Sciatica
- Open Targets ID
- HP_0011868
- Highest stage of its drugs
- Phase 3, for 10 of its 18 drugs, from ClinicalTrials.gov and TTD
Source Open Targets
Drugs18
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| DEXAMETHASONE | CHEMBL384467 | Small molecule | Phase 3 | ClinicalTrials.gov | 3 | 3 | 3 | Drugs and targets |
| ADALIMUMAB | CHEMBL1201580 | Antibody | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| DICLOFENAC | CHEMBL139 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| PREDNISONE | CHEMBL635 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| CODEINE PHOSPHATE | CHEMBL6067642 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| DEXAMETHASONE SODIUM PHOSPHATE | CHEMBL2021430 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| INFLIXIMAB | CHEMBL1201581 | Antibody | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| LACOSAMIDE | CHEMBL58323 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| PREDNISOLONE ACETATE | CHEMBL1152 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| ETANERCEPT | CHEMBL1201572 | Protein | Phase 3 | TTD | 1 | 0 | 0 | Drugs and targets |
1 to 10 of 18
See all 18 drugsTargets46
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| NR3C1 | Glucocorticoid receptor | 5 | Glucocorticoid receptor agonist | Phase 3 | https://conductscience.org/library/genes/2908 | Drugs and targets |
| TNF | Tumor necrosis factor | 4 | TNF-alpha inhibitor | Phase 3 | https://conductscience.org/library/genes/7124 | Drugs and targets |
| OPRM1 | Mu-type opioid receptor | 2 | Mu opioid receptor agonist; Opioid receptors; mu/kappa/delta agonist | Phase 3 | https://conductscience.org/library/genes/4988 | Drugs and targets |
| SCN10A | Sodium channel alpha subunit | 2 | Sodium channel alpha subunit blocker | Phase 3 | https://conductscience.org/library/genes/6336 | Drugs and targets |
| SCN11A | Sodium channel alpha subunit | 2 | Sodium channel alpha subunit blocker | Phase 3 | https://conductscience.org/library/genes/11280 | Drugs and targets |
| SCN1A | Sodium channel alpha subunit | 2 | Sodium channel alpha subunit blocker | Phase 3 | https://conductscience.org/library/genes/6323 | Drugs and targets |
| SCN2A | Sodium channel alpha subunit | 2 | Sodium channel alpha subunit blocker | Phase 3 | https://conductscience.org/library/genes/6326 | Drugs and targets |
| SCN3A | Sodium channel alpha subunit | 2 | Sodium channel alpha subunit blocker | Phase 3 | https://conductscience.org/library/genes/6328 | Drugs and targets |
| SCN4A | Sodium channel alpha subunit | 2 | Sodium channel alpha subunit blocker | Phase 3 | https://conductscience.org/library/genes/6329 | Drugs and targets |
| SCN5A | Sodium channel alpha subunit | 2 | Sodium channel alpha subunit blocker | Phase 3 | https://conductscience.org/library/genes/6331 | Drugs and targets |
1 to 10 of 46
See all 46 targetsTrials17
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT00668434 | Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica | Phase 2 | 269 | 2015-04-28 | Sciatica | PREDNISONE | Its record names the disease | ClinicalTrials.gov |
| NCT07579351 | Corticosteroid Lumbar Epidural Analgesia for Radicular Pain 2 | Phase 3 | 755 | Lumbosacral Radicular Pain | DEXAMETHASONE SODIUM PHOSPHATE | Its record names the disease | ClinicalTrials.gov | |
| NCT02087462 | Electroacupuncture for Sciatica Due to Intervertebral Disc Displacement | Not applicable | 324 | Sciatica Due to Intervertebral Disc Disorder | DICLOFENAC, THIAMINE | Its record names the disease | ClinicalTrials.gov | |
| NCT00317447 | The Efficacy of Oral Steroids in the Treatment of Acute Sciatica | Phase 3 | 160 | Sciatica | PREDNISONE | Its record names the disease | ClinicalTrials.gov | |
| NCT05626140 | COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA | Phase 3 | 120 | Sciatica Acute, Sciatica | CODEINE PHOSPHATE, DICLOFENAC, LACOSAMIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT05000658 | Efficacy of Soluble Dexamethasone in Refractory Sciatica | Phase 3 | 109 | Sciatica | DEXAMETHASONE | Its record names the disease | ClinicalTrials.gov | |
| NCT01510548 | ADALISKIAS: Adalimumab for Acute Disc Prolapse | Phase 3 | 90 | Disc Prolapse, Pain | ADALIMUMAB | Its record names the disease | ClinicalTrials.gov | |
| NCT00009672 | Pain Treatment for Sciatica | Phase 2 | 80 | Radiculopathy, Sciatica | MORPHINE, NORTRIPTYLINE | Its record names the disease | ClinicalTrials.gov | |
| NCT06817018 | Ginger Root Extract for Sciatic Pain Individuals | Phase 2 | 80 | Neuropathic Pain, Sciatic Pain | GINGER | Its record names the disease | ClinicalTrials.gov | |
| NCT00011804 | Topiramate in the Treatment of Sciatica | Phase 2 | 65 | Sciatica | TOPIRAMATE | Its record names the disease | ClinicalTrials.gov |
1 to 10 of 17
See all 17 trialsComparisons in its trials1
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial |
|---|---|---|---|---|
| Prednisone vs Placebo: serious adverse events | 3 of 181 | 2 of 88 | 269 | NCT00668434 |
Source Trial comparisons
Papers from its trials7
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/HP_0011868
GET https://conductscience.org/api/diseases/v1/HP_0011868/targets?page=2