Disease · MONDO_0002959

radiculopathy

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. radiculopathy. Diseases, record MONDO_0002959. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0002959

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: radiculopathy; Open Targets
Open Targets ID: MONDO_0002959; Open Targets
Other names: nerve root disorder; Open Targets
Disease Ontology: DOID:4306; Disease Ontology
MeSH: D011843; MeSH
Highest stage of its drugs: Phase 3, for 1 of its 10 drugs, from ClinicalTrials.gov; Open Targets

Drugs10

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
LOXOPROFEN	CHEMBL19299	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
ETANERCEPT	CHEMBL1201572	Protein	Phase 2/3	ClinicalTrials.gov	2	2	2	Drugs and targets
METHYLPREDNISOLONE	CHEMBL650	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
DEXAMETHASONE	CHEMBL384467	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
PREDNISONE	CHEMBL635	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
VIXOTRIGINE	CHEMBL3544913	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
Z160	CHEMBL604710	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
LACTIC ACID	CHEMBL1200559	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
CLONIDINE	CHEMBL134	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
TRIAMCINOLONE HEXACETONIDE	CHEMBL1200878	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets9

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
NR3C1	Glucocorticoid receptor	4	Glucocorticoid receptor agonist	Phase 2/3	https://conductscience.org/library/genes/2908	Drugs and targets
ADRA2A	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Unknown	https://conductscience.org/library/genes/150	Drugs and targets
ADRA2B	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Unknown	https://conductscience.org/library/genes/151	Drugs and targets
ADRA2C	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Unknown	https://conductscience.org/library/genes/152	Drugs and targets
CACNA1B	Voltage-dependent N-type calcium channel subunit alpha-1B	1	Voltage-gated N-type calcium channel alpha-1B subunit blocker	Phase 2	https://conductscience.org/library/genes/774	Drugs and targets
PTGS1	Cyclooxygenase	1	Cyclooxygenase inhibitor	Phase 3	https://conductscience.org/library/genes/5742	Drugs and targets
PTGS2	Cyclooxygenase	1	Cyclooxygenase inhibitor	Phase 3	https://conductscience.org/library/genes/5743	Drugs and targets
SCN9A	Sodium channel protein type 9 subunit alpha	1	Sodium channel protein type IX alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6335	Drugs and targets
TNF	Tumor necrosis factor	1	TNF-alpha inhibitor	Phase 2/3	https://conductscience.org/library/genes/7124	Drugs and targets

Trials10

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00668434	Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica	Phase 2	269	2015-04-28	Sciatica	PREDNISONE	Its record names the disease	ClinicalTrials.gov
NCT00733096	A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy	Phase 2/3	84	2012-10-08	Lumbosacral Radiculopathy	ETANERCEPT, METHYLPREDNISOLONE	Open Targets' reading of its record	ClinicalTrials.gov
NCT03389620	Transforaminal Versus Lateralized Interlaminar Cervical Epidurals	Phase 2	74	2025-12-19	Cervicogenic Upper Extremity Radiculopathy	DEXAMETHASONE	Its record names the disease	ClinicalTrials.gov
NCT00588354	Epidural Clonidine for Lumbosacral Radiculopathy	Not applicable	26	2012-01-11	Lumbar and Other Intervertebral Disc Disorders With Radiculopathy	CLONIDINE, TRIAMCINOLONE HEXACETONIDE	Its record names the disease	ClinicalTrials.gov
NCT01655849	Phase 2 Efficacy Trial of Z160 in Lumbosacral Radiculopathy	Phase 2	141		Lumbosacral Radiculopathy	Z160	Open Targets' reading of its record	ClinicalTrials.gov
NCT00308594	Oral Dexamethasone for the Treatment of Cervical Radiculopathy	Phase 2	100		Cervical Radiculopathy	DEXAMETHASONE	Open Targets' reading of its record	ClinicalTrials.gov
NCT01561027	Crossover Study of CNV1014802 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy	Phase 2	82		Lumbosacral Radiculopathy	VIXOTRIGINE	Open Targets' reading of its record	ClinicalTrials.gov
NCT03386149	Clinical Research on the Efficacy of Bosinji on Herniated Intervertebral Disc of Lumbar Spine	Phase 3	74		Lumbar Disc Herniation	LOXOPROFEN	Its record names the disease	ClinicalTrials.gov
NCT06022263	STA363 in the Treatment of Lumbar Disc Herniation	Phase 1	25		Lumbar Disc Herniation	LACTIC ACID	Its record names the disease	ClinicalTrials.gov
NCT00364572	Efficacy of Epidural Etanercept in the Treatment of Sciatica	Phase 1/2	24		Sciatica	ETANERCEPT	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Prednisone vs Placebo: serious adverse events	3 of 181	2 of 88	269	NCT00668434	Trial comparisons
Transforaminal Cervical Epidural Corticosteroid Injections vs Lateralized Interlaminar Epidural Corticosteroid Injections: deaths from any cause	0 of 37	0 of 37	74	NCT03389620	Trial comparisons
Transforaminal Cervical Epidural Corticosteroid Injections vs Lateralized Interlaminar Epidural Corticosteroid Injections: serious adverse events	0 of 37	0 of 37	74	NCT03389620	Trial comparisons
2% Lidocaine and Clonidine (200 or 400 ug) vs 2% Lidocaine and Triamcinolone (40 mg).: serious adverse events	0 of 11	0 of 15	26	NCT00588354	Trial comparisons

Papers from its trials14

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
21192304	RESULT	1	PubMed
16371894	RESULT	1	PubMed
16192528	RESULT	1	PubMed
15454701	RESULT	1	PubMed
15115710	RESULT	1	PubMed
12897484	RESULT	1	PubMed
12384756	RESULT	1	PubMed
11145807	RESULT	1	PubMed
9854752	RESULT	1	PubMed
39640075	DERIVED	1	PubMed

1 to 10 of 14

See all 14 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0002959

GET https://conductscience.org/api/diseases/v1/MONDO_0002959/drugs

API reference For AI assistants