Disease · MONDO_0005076

periodontitis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. periodontitis. Diseases, record MONDO_0005076. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005076

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: periodontitis; Open Targets
Open Targets ID: MONDO_0005076; Open Targets
Other names: Pericementitides, Pericementitis, Periodontitides, Periodontitis (disorder), Periodontitis, NOS, inflammation of periodontium, periodontium inflammation; Open Targets
Disease Ontology: DOID:824; Disease Ontology
Disease Ontology: DOID:9893; Disease Ontology
MeSH: D010518; MeSH
NCI Thesaurus: C34918; NCI Thesaurus
Highest stage of its drugs: Approval, for 5 of its 86 drugs, from DailyMed and PMDA; Open Targets

Drugs86

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
DOXYCYCLINE	CHEMBL1200699	Small molecule	Approval	DailyMed	11	8	8	Drugs and targets
CHLORHEXIDINE GLUCONATE	CHEMBL4297088	Small molecule	Approval	DailyMed	5	4	4	Drugs and targets
MINOCYCLINE HYDROCHLORIDE	CHEMBL1200881	Small molecule	Approval	DailyMed	5	4	4	Drugs and targets
TRAFERMIN	CHEMBL2108081	Protein	Approval	PMDA	4	2	2	Drugs and targets
SODIUM MONOFLUOROPHOSPHATE	CHEMBL1908359	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
METRONIDAZOLE	CHEMBL137	Small molecule	Phase 3	ClinicalTrials.gov	23	23	23	Drugs and targets
CHLORHEXIDINE	CHEMBL790	Small molecule	Phase 3	ClinicalTrials.gov	17	17	17	Drugs and targets
AMOXICILLIN	CHEMBL1082	Small molecule	Phase 3	ClinicalTrials.gov	14	14	14	Drugs and targets
HYALURONIC ACID	CHEMBL5314376		Phase 3	ClinicalTrials.gov	14	14	14	Drugs and targets
CURCUMIN	CHEMBL140	Small molecule	Phase 3	ClinicalTrials.gov	6	6	6	Drugs and targets

1 to 10 of 86

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Targets70

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
HMGCR	3-hydroxy-3-methylglutaryl-coenzyme A reductase	5	HMG-CoA reductase inhibitor	Phase 2/3	https://conductscience.org/library/genes/3156	Drugs and targets
PTGS1	Cyclooxygenase	5	Cyclooxygenase inhibitor	Phase 2/3	https://conductscience.org/library/genes/5742	Drugs and targets
PTGS2	Cyclooxygenase	5	Cyclooxygenase inhibitor	Phase 2/3	https://conductscience.org/library/genes/5743	Drugs and targets
NR3C1	Glucocorticoid receptor	4	Glucocorticoid receptor agonist	Unknown	https://conductscience.org/library/genes/2908	Drugs and targets
MMP1	Interstitial collagenase	2	Matrix metalloproteinase-1 inhibitor	Approval	https://conductscience.org/library/genes/4312	Drugs and targets
MMP13	Collagenase 3	2	Matrix metalloproteinase 13 inhibitor	Approval	https://conductscience.org/library/genes/4322	Drugs and targets
MMP7	Matrilysin	2	Matrix metalloproteinase 7 inhibitor	Approval	https://conductscience.org/library/genes/4316	Drugs and targets
MMP8	Neutrophil collagenase	2	Matrix metalloproteinase 8 inhibitor	Approval	https://conductscience.org/library/genes/4317	Drugs and targets
VDR	Vitamin D3 receptor	2	Vitamin D receptor agonist	Phase 2	https://conductscience.org/library/genes/7421	Drugs and targets
CNR1	Cannabinoid receptor 1	1	Cannabinoid CB1 receptor negative allosteric modulator	Phase 1/2	https://conductscience.org/library/genes/1268	Drugs and targets

1 to 10 of 70

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Trials150

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 11 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00066066	Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers	Phase 2	146	2013-04-22	Periodontitis, Periodontal Diseases	AMOXICILLIN, DOXYCYCLINE, METRONIDAZOLE	Its record names the disease	ClinicalTrials.gov
NCT02709785	SmartMouth Advanced Clinical Formula Clinical Research Design Protocol	Not applicable	80	2018-12-04	Gingivitis, Periodontitis	CETYLPYRIDINIUM CHLORIDE, CHLORHEXIDINE	Its record names the disease	ClinicalTrials.gov
NCT05258721	Efficacy of ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse Regimen on MGI, PI and BOP	Phase 2	60	2023-03-15	Gingivitis, Periodontitis	FLUORIDE	Its record names the disease	ClinicalTrials.gov
NCT01976806	The Effects of DHA on Periodontitis	Phase 2	55	2014-03-24	Periodontitis, Gingivitis, Inflammation	ASPIRIN, DOCONEXENT	Its record names the disease	ClinicalTrials.gov
NCT05530252	Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis	Phase 4	51	2024-04-30	Periodontitis	MINOCYCLINE HYDROCHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT02969928	Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis	Phase 2/3	46	2020-09-07	Aggressive Periodontitis	AMOXICILLIN, CLARITHROMYCIN, METRONIDAZOLE	Its record names the disease	ClinicalTrials.gov
NCT03374176	Efficacy of Amoxicillin-metronidazole Compared to Clindamycin in Patients With Periodontitis and Diabetes	Phase 3	42	2020-06-23	Periodontitis, Periodontal Pocket, Diabetes Mellitus	AMOXICILLIN, CLINDAMYCIN, METRONIDAZOLE	Its record names the disease	ClinicalTrials.gov
NCT00779909	Dose-dependent Anti-inflammatory Effects of Vitamin D in a Human Gingivitis Model	Early phase 1	35	2017-10-02	Gingivitis	CHOLECALCIFEROL	Its record names the disease	ClinicalTrials.gov
NCT06027151	Comparing the Efficacy of Metronidazole and Minocycline Gels for the Treatment of Diabetic Periodontitis Patients	Not applicable	380		Periodontitis, Diabetes Mellitus	METRONIDAZOLE, MINOCYCLINE	Its record names the disease	ClinicalTrials.gov
NCT00734708	Phase 3 Clinical Trial of Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2(Trafermin)	Phase 3	328		Periodontitis, Alveolar Bone Loss, Periodontal Attachment Loss	TRAFERMIN	Its record names the disease	ClinicalTrials.gov

1 to 10 of 150

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Comparisons in its trials5

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
DHA 2 gm (4 Caps) + Aspirin 81 mg (1 Tablet by Mouth Per Day) vs Placebo (4 Caps) + Aspirin 81 mg (1 Tablet by Mouth Per Day): serious adverse events	0 of 27	0 of 28	55	NCT01976806	Trial comparisons
Amoxicillin and Metronidazole vs Clarithromycin: deaths from any cause	0 of 23	0 of 23	46	NCT02969928	Trial comparisons
Amoxicillin and Metronidazole vs Clarithromycin: serious adverse events	0 of 23	0 of 23	46	NCT02969928	Trial comparisons
AMX-MET vs Clindamycin: deaths from any cause	0 of 21	0 of 21	42	NCT03374176	Trial comparisons
AMX-MET vs Clindamycin: serious adverse events	0 of 21	0 of 21	42	NCT03374176	Trial comparisons

Papers from its trials92

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
39275820	RESULT	1	PubMed
38594113	RESULT	1	PubMed
35968157	RESULT	1	PubMed
35420698	RESULT	1	PubMed
35287956	RESULT	1	PubMed
34134691	RESULT	1	PubMed
32844406	RESULT	1	PubMed
31994207	RESULT	1	PubMed
31620939	RESULT	1	PubMed
30931588	RESULT	1	PubMed

1 to 10 of 92

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005076

GET https://conductscience.org/api/diseases/v1/MONDO_0005076/drugs?page=2

API reference For AI assistants