Disease · MONDO_0005267

heart disorder

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. heart disorder. Diseases, record MONDO_0005267. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005267

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: heart disorder; Open Targets
Open Targets ID: MONDO_0005267; Open Targets
Other names: CARDIAC DIS, Cardiac Diseases, Disease, Cardiac, Disease, Heart, Diseases, Cardiac, Diseases, Heart, HEART DIS, Heart Diseases, cardiac disease, disease of heart, disease or disorder of heart, disorder of heart, disorder of heart/pericardium, heart disease, heart disease or disorder, heart trouble, heart/pericardial disease, heart/pericardial disease or disorder, heart/pericardial disorder, heart/pericardial trouble; Open Targets
Disease Ontology: DOID:114; Disease Ontology
MeSH: D006331; MeSH
NCI Thesaurus: C3079; NCI Thesaurus
Highest stage of its drugs: Approval, for 4 of its 56 drugs, from TTD; Open Targets

Drugs56

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
DENOPAMINE	CHEMBL493682	Small molecule	Approval	TTD	1	0	0	Drugs and targets
IBOPAMINE	CHEMBL307739	Small molecule	Approval	TTD	1	0	0	Drugs and targets
INAMRINONE LACTATE	CHEMBL2096642	Small molecule	Approval	TTD	1	0	0	Drugs and targets
PERFLUBUTANE	CHEMBL2104979	Small molecule	Approval	TTD	1	0	0	Drugs and targets
EMPAGLIFLOZIN	CHEMBL2107830	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
HEPARIN SODIUM	CHEMBL1201657	Oligosaccharide	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
COLCHICINE	CHEMBL107	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
GLYBURIDE	CHEMBL472	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
PARICALCITOL	CHEMBL1200622	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
PIOGLITAZONE	CHEMBL595	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets

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Targets115

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
GNRHR	Gonadotropin-releasing hormone receptor	5	Gonadotropin-releasing hormone receptor agonist; Gonadotropin-releasing hormone receptor antagonist	Early phase 1	https://conductscience.org/library/genes/2798	Drugs and targets
ADRB1	Adrenergic receptor	3	Adrenergic receptor agonist; Beta-1 adrenergic receptor antagonist	Phase 2	https://conductscience.org/library/genes/153	Drugs and targets
ADRB2	Adrenergic receptor	2	Adrenergic receptor agonist; Beta-2 adrenergic receptor antagonist	Phase 2	https://conductscience.org/library/genes/154	Drugs and targets
AGTR1	Type-1 angiotensin II receptor	2	Type-1 angiotensin II receptor agonist; Type-1 angiotensin II receptor antagonist	Phase 2	https://conductscience.org/library/genes/185	Drugs and targets
HMGCR	3-hydroxy-3-methylglutaryl-coenzyme A reductase	2	HMG-CoA reductase inhibitor	Phase 3	https://conductscience.org/library/genes/3156	Drugs and targets
LHCGR	Lutropin-choriogonadotropic hormone receptor	2	Luteinizing hormone/Choriogonadotropin receptor agonist	Unknown	https://conductscience.org/library/genes/3973	Drugs and targets
PAH	Phenylalanine-4-hydroxylase	2	Phenylalanine-4-hydroxylase activator	Early phase 1	https://conductscience.org/library/genes/5053	Drugs and targets
PPARG	Peroxisome proliferator-activated receptor gamma	2	Peroxisome proliferator-activated receptor gamma agonist	Phase 3	https://conductscience.org/library/genes/5468	Drugs and targets
ABCC8	Sulfonylurea receptor 1, Kir6.2	1	Sulfonylurea receptor 1, Kir6.2 blocker	Phase 3	https://conductscience.org/library/genes/6833	Drugs and targets
ADRA1A	Adrenergic receptor	1	Adrenergic receptor agonist	Phase 1	https://conductscience.org/library/genes/148	Drugs and targets

1 to 10 of 115

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Trials22

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00608062	Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women	Not applicable	155	2020-12-24	Arterial Stiffening, Aging, Menopause	ESTRADIOL, GANIRELIX ACETATE	Its record names the disease	ClinicalTrials.gov
NCT00577590	Effects of Fatty Acid Delivery on Heart Metabolism and Function in Type 2 Diabetes (T2DM	Not applicable	78	2018-08-31	Diabetes Mellitus, Type II	METFORMIN, OMEGA-3-ACID ETHYL ESTERS, ROSIGLITAZONE	Its record names the disease	ClinicalTrials.gov
NCT02740179	Effects of Eplerenone on Cardiovascular Disease in HIV (MIRACLE HIV Study)	Not applicable	40	2023-06-02	HIV	EPLERENONE	Its record names the disease	ClinicalTrials.gov
NCT00565916	Evaluating the Roles of Estrogen and Progesterone in Heart Metabolism	Not applicable	22	2018-10-16	Postmenopausal Syndrome	ESTROGEN, PROGESTERONE	Open Targets' reading of its record	ClinicalTrials.gov
NCT01012414	Effect of Vitamin D Supplement on Inflammation Markers in High-Risk Cardiovascular Patients With Chronic Kidney Disease	Phase 3	10	2013-11-11	Coronary Artery Disease, Chronic Kidney Disease, Hypovitaminosis D, Secondary Hyperparathyroidism	PARICALCITOL	Its record names the disease	ClinicalTrials.gov
NCT07232069	PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis	Phase 3	1,500		Coronary Artery Disease Risk Factors Multiple, Coronary Artery Disease Progression, Prevention & Control, Premature Atherosclerosis	COLCHICINE, ROSUVASTATIN	Its record names the disease	ClinicalTrials.gov
NCT00000623	Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN)		1,000		Anemia, Cooley's, Beta-Thalassemia, Hematologic Diseases, Thalassemia, Osteoporosis, Iron Overload, Hypertension, Pulmonary	ARGININE, DECITABINE, DEFERIPRONE, DEFEROXAMINE, SILDENAFIL	Its record names the disease	ClinicalTrials.gov
NCT00521742	Efficacy of Pioglitazone Compared to Glyburide in Treating Subjects With Type 2 Diabetes Mellitus and Mild Cardiac Disease	Phase 3	300		Diabetes Mellitus	GLYBURIDE, PIOGLITAZONE	Its record names the disease	ClinicalTrials.gov
NCT02758431	Cardiovascular Outcomes of Low Testosterone	Not applicable	232		Hypogonadism	TESTOSTERONE	Its record names the disease	ClinicalTrials.gov
NCT07169981	Effect of Empagliflozin 10 vs 25 mg on LV Remodeling in Diabetic Patients With Anterior STEMI With Reduced LVEF	Phase 2	200		Diabete Mellitus, Heart Failure, Remodeling, Left Ventricle	EMPAGLIFLOZIN	Its record names the disease	ClinicalTrials.gov

1 to 10 of 22

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Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Eplerenone vs Placebo: deaths from any cause	1 of 20	0 of 20	40	NCT02740179	Trial comparisons
Eplerenone vs Placebo: serious adverse events	1 of 20	0 of 20	40	NCT02740179	Trial comparisons
Estrogen Plus Progesterone vs Estrogen Plus Placebo: deaths from any cause	0 of 11	0 of 11	22	NCT00565916	Trial comparisons
Estrogen Plus Progesterone vs Estrogen Plus Placebo: serious adverse events	0 of 11	0 of 11	22	NCT00565916	Trial comparisons

Papers from its trials15

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
22969140	RESULT	1	PubMed
20557330	RESULT	1	PubMed
41994349	DERIVED	1	PubMed
40478895	DERIVED	1	PubMed
39843293	DERIVED	1	PubMed
38813261	DERIVED	1	PubMed
38090987	DERIVED	1	PubMed
37559752	DERIVED	1	PubMed
37243345	DERIVED	1	PubMed
35061894	DERIVED	1	PubMed

1 to 10 of 15

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005267

GET https://conductscience.org/api/diseases/v1/MONDO_0005267/drugs?page=2

API reference For AI assistants