Disease · MONDO_0005406
gestational diabetes
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. gestational diabetes. Diseases, record MONDO_0005406. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005406
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Other names
- diabetes in pregnancy, gestational diabetes mellitus, maternal gestational diabetes mellitus
- Open Targets
Drugs28
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| METFORMIN | CHEMBL1431 | Small molecule | Phase 3 | ClinicalTrials.gov | 30 | 30 | 30 | Drugs and targets |
| INSULIN HUMAN | CHEMBL1201631 | Protein | Phase 3 | ClinicalTrials.gov | 22 | 22 | 22 | Drugs and targets |
| GLYBURIDE | CHEMBL472 | Small molecule | Phase 3 | ClinicalTrials.gov | 9 | 9 | 9 | Drugs and targets |
| INSULIN ASPART | CHEMBL1201496 | Protein | Phase 3 | ClinicalTrials.gov | 3 | 3 | 3 | Drugs and targets |
| INSULIN GLARGINE | CHEMBL1201497 | Protein | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| ACARBOSE | CHEMBL404271 | Oligosaccharide | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| EMPAGLIFLOZIN | CHEMBL2107830 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| INSULIN HUMAN, ISOPHANE | CHEMBL2108973 | Protein | Phase 3 | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
| LIRAGLUTIDE | CHEMBL4084119 | Protein | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| METFORMIN HYDROCHLORIDE | CHEMBL1703 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
1 to 10 of 28
See all 28 drugsTargets77
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| INSR | Insulin receptor | 8 | Insulin receptor agonist | Phase 3 | https://conductscience.org/library/genes/3643 | Drugs and targets |
| ADRA1A | Adrenergic receptor | 3 | Adrenergic receptor agonist; Adrenergic receptor alpha-1 agonist | Unknown | https://conductscience.org/library/genes/148 | Drugs and targets |
| ADRA1B | Adrenergic receptor | 3 | Adrenergic receptor agonist; Adrenergic receptor alpha-1 agonist | Unknown | https://conductscience.org/library/genes/147 | Drugs and targets |
| ADRA1D | Adrenergic receptor | 3 | Adrenergic receptor agonist; Adrenergic receptor alpha-1 agonist | Unknown | https://conductscience.org/library/genes/146 | Drugs and targets |
| ADRA2A | Adrenergic receptor | 2 | Adrenergic receptor agonist | Unknown | https://conductscience.org/library/genes/150 | Drugs and targets |
| ADRA2B | Adrenergic receptor | 2 | Adrenergic receptor agonist | Unknown | https://conductscience.org/library/genes/151 | Drugs and targets |
| ADRA2C | Adrenergic receptor | 2 | Adrenergic receptor agonist | Unknown | https://conductscience.org/library/genes/152 | Drugs and targets |
| ADRB1 | Adrenergic receptor | 2 | Adrenergic receptor agonist | Unknown | https://conductscience.org/library/genes/153 | Drugs and targets |
| ADRB2 | Adrenergic receptor | 2 | Adrenergic receptor agonist | Unknown | https://conductscience.org/library/genes/154 | Drugs and targets |
| ADRB3 | Adrenergic receptor | 2 | Adrenergic receptor agonist | Unknown | https://conductscience.org/library/genes/155 | Drugs and targets |
1 to 10 of 77
See all 77 targetsTrials56
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT02932475 | Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD) | Phase 3 | 831 | 2023-05-24 | Diabetes, Pregnancy | METFORMIN | Its record names the disease | ClinicalTrials.gov |
| NCT02980276 | RCT Metformin for Reduction of Gestational Diabetes Mellitus Effects | Phase 3 | 535 | 2025-03-17 | Gestational Diabetes | METFORMIN, METFORMIN HYDROCHLORIDE | Its record names the disease | ClinicalTrials.gov |
| NCT01234649 | Combined Liraglutide and Metformin Therapy in Women With Previous Gestational Diabetes Mellitus (GDM) | Phase 3 | 153 | 2019-07-26 | Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus, Metabolic Syndrome, Impaired Glucose Tolerance, Disorder of Glucose Regulation | LIRAGLUTIDE, METFORMIN | Its record names the disease | ClinicalTrials.gov |
| NCT00965991 | Metformin Compared to Glyburide in Gestational Diabetes | Not applicable | 149 | 2023-12-21 | Gestational Diabetes | GLYBURIDE, METFORMIN | Its record names the disease | ClinicalTrials.gov |
| NCT01837680 | Glycemic Control Using Insulin Levemir Versus Insulin NPH for Diabetes in Pregnancy | Not applicable | 105 | 2017-05-30 | Diabetes, Gestational, Diabetes, Type 2 | INSULIN DETEMIR, PROTAMINE SULFATE | Its record names the disease | ClinicalTrials.gov |
| NCT03106870 | Adding Metformin to Insulin in Controlling Pregestational and Gestational Diabetes Mellitus | Not applicable | 62 | 2017-06-14 | Gestational Diabetes Mellitus in Pregnancy | INSULIN HUMAN, METFORMIN | Its record names the disease | ClinicalTrials.gov |
| NCT00835861 | Effectiveness of Metformin Compared to Insulin in Pregnant Women With Mild Preexisting or Early Gestational Diabetes | Phase 2 | 31 | 2014-05-26 | Non Insulin Dependent Diabetes, Pregnancy | INSULIN HUMAN, METFORMIN | Its record names the disease | ClinicalTrials.gov |
| NCT01998113 | Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. Systematic Review | 2,509 | Gestational Diabetes Mellitus | GLYBURIDE, METFORMIN | Its record names the disease | ClinicalTrials.gov | ||
| NCT01731431 | Multicenter Randomized Trial of Non-inferiority Between Glyburide and Insulin for the Treatment of Gestational Diabetes | Phase 3 | 914 | Diabetes, Gestational | GLYBURIDE, INSULIN HUMAN | Its record names the disease | ClinicalTrials.gov | |
| NCT02947503 | Pregnancy Outcomes: Effects of Metformin Study (POEM Study) | Phase 3 | 500 | Gestational Diabetes, Insulin Resistance | METFORMIN | Its record names the disease | ClinicalTrials.gov |
1 to 10 of 56
See all 56 trialsComparisons in its trials44
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Metformin vs Placebo: Number of Participants With Composite Adverse Neonatal Outcome | 269 of 386 | 277 of 382 | 768 | NCT02932475 | Trial comparisons |
| Treatment vs Control: Insulation of Insulin | 101 of 264 | 134 of 262 | 526 | NCT02980276 | Trial comparisons |
| Treatment vs Control: Primary Composite Outcome | 150 of 264 | 167 of 262 | 526 | NCT02980276 | Trial comparisons |
| Treatment vs Control: Insulin Initiated | 94 of 263 | 106 of 262 | 525 | NCT02980276 | Trial comparisons |
| Treatment vs Control: Neonatal Morbidity - Neonatal Hypoglycemia | 36 of 262 | 34 of 262 | 524 | NCT02980276 | Trial comparisons |
| Treatment vs Control: Neonatal Morbidity - Apgar Score <7 at 5 Minutes | 1 of 262 | 1 of 262 | 524 | NCT02980276 | Trial comparisons |
| Treatment vs Control: Maternal Morbidity - Antepartum Hemorrhage | 15 of 262 | 27 of 262 | 524 | NCT02980276 | Trial comparisons |
| Treatment vs Control: Neonatal Morbidity - Major Congenital Anomalies | 10 of 262 | 7 of 262 | 524 | NCT02980276 | Trial comparisons |
| Treatment vs Control: Maternal Morbidity - Postpartum Hemorrhage | 51 of 262 | 63 of 262 | 524 | NCT02980276 | Trial comparisons |
| Treatment vs Control: Neonatal Morbidity - Jaundice Requiring Phototherapy | 1 of 262 | 0 of 262 | 524 | NCT02980276 | Trial comparisons |
1 to 10 of 44
See all 44 comparisons in its trialsPapers from its trials44
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0005406
GET https://conductscience.org/api/diseases/v1/MONDO_0005406/drugs?page=2