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Disease · MONDO_0005420

hypothyroidism

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. hypothyroidism. Diseases, record MONDO_0005420. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005420

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
hypothyroidism
Open Targets
Open Targets ID
MONDO_0005420
Open Targets
Other names
underactive thyroid
Open Targets
Disease Ontology
DOID:1459
Disease Ontology
MeSH
D007037
MeSH
NCI Thesaurus
C26800
NCI Thesaurus
Highest stage of its drugs
Approval, for 10 of its 18 drugs, from DailyMed, PMDA and TTD
Open Targets

Drugs18

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
LEVOTHYROXINECHEMBL1624Small moleculeApprovalTTD454444Drugs and targets
LIOTHYRONINECHEMBL1544Small moleculeApprovalTTD131212Drugs and targets
LEVOTHYROXINE SODIUMCHEMBL2103741Small moleculeApprovalDailyMed and PMDA13888Drugs and targets
LIOTHYRONINE SODIUMCHEMBL1201119Small moleculeApprovalDailyMed422Drugs and targets
CHOLESTYRAMINECHEMBL1201625ApprovalDailyMed100Drugs and targets
FENOFIBRATECHEMBL672Small moleculeApprovalDailyMed100Drugs and targets
MECASERMINCHEMBL1201716ProteinApprovalDailyMed100Drugs and targets
OMEGA-3-ACID ETHYL ESTERSCHEMBL1200711Small moleculeApprovalDailyMed100Drugs and targets
THYROGLOBULINCHEMBL1201650ApprovalTTD100Drugs and targets
THYROTROPINCHEMBL1201532ApprovalTTD100Drugs and targets

1 to 10 of 18

See all 18 drugs

Targets10

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
THRAThyroid hormone receptor4Thyroid hormone receptor agonistApprovalhttps://conductscience.org/library/genes/7067Drugs and targets
THRBThyroid hormone receptor4Thyroid hormone receptor agonistApprovalhttps://conductscience.org/library/genes/7068Drugs and targets
DIO1Type I iodothyronine deiodinase1Type I iodothyronine deiodinase (Type-I 5'-deiodinase) (DIOI) (Type 1 DI) (5DI) inhibitorUnknownhttps://conductscience.org/library/genes/1733Drugs and targets
IGF1RInsulin-like growth factor 1 receptor1Insulin-like growth factor I receptor agonistApprovalhttps://conductscience.org/library/genes/3480Drugs and targets
PPARAPeroxisome proliferator-activated receptor alpha1Peroxisome proliferator-activated receptor alpha agonistApprovalhttps://conductscience.org/library/genes/5465Drugs and targets
TLR7Toll-like receptor 71Toll-like receptor 7 antagonistUnknownhttps://conductscience.org/library/genes/51284Drugs and targets
TLR9Toll-like receptor 91Toll-like receptor 9 antagonistUnknownhttps://conductscience.org/library/genes/54106Drugs and targets
TPOThyroid peroxidase1Thyroid peroxidase inhibitorUnknownhttps://conductscience.org/library/genes/7173Drugs and targets
TSHRThyrotropin receptor1Thyroid stimulating hormone receptor agonistApprovalhttps://conductscience.org/library/genes/7253Drugs and targets
VDRVitamin D3 receptor1Vitamin D receptor agonistPhase 3https://conductscience.org/library/genes/7421Drugs and targets

Trials59

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT00388297Thyroid Therapy for Mild Thyroid Deficiency in PregnancyPhase 31,2032019-01-30Subclinical Hypothyroidism, Hypothyroxinemia, PregnancyLEVOTHYROXINEOpen Targets' reading, confirmed by NLM's indexing of its papersClinicalTrials.gov
NCT04124705A Study of Armour® Thyroid Compared to Synthetic T4 (Levothyroxine) in Previously Hypothyroid ParticipantsPhase 22842024-06-05Hypothyroidism, Thyroid Disease, Euthyroid, Thyroid Gland, Thyroid HormonesLEVOTHYROXINE, THYROIDIts record names the diseaseClinicalTrials.gov
NCT00565864Neurocognitive and Metabolic Effects of Mild HypothyroidismPhase 41732018-08-22HypothyroidismLEVOTHYROXINEIts record names the diseaseClinicalTrials.gov
NCT01916304Study of Dose Adjustment From Levothyroxine to a New Levothyroxine Sodium Test FormulationPhase 21012015-07-20HypothyroidismLEVOTHYROXINEIts record names the diseaseClinicalTrials.gov
NCT03880578Quality of Life After Interventional Thyroid Treatment1012024-10-29Thyroid; Deficiency, Quality of LifeLEVOTHYROXINE SODIUMIts record names the diseaseClinicalTrials.gov
NCT03094416Levothyroxine Sodium in Thyroidectomized Patients Taking Proton Pump InhibitorsPhase 4662022-04-05Hypothyroidism;PostablativeLEVOTHYROXINE SODIUMIts record names the diseaseClinicalTrials.gov
NCT00230802Thyroid Hormone Dose Adjustment in PregnancyNot applicable482016-12-23Pregnancy, HypothyroidismLEVOTHYROXINEIts record names the diseaseClinicalTrials.gov
NCT05823012Study of XP-8121 For the Treatment of Adult Subjects With HypothyroidismPhase 2462025-07-03HypothyroidismLEVOTHYROXINE SODIUMIts record names the diseaseClinicalTrials.gov
NCT00106119Thyroid and Glucose and Energy MetabolismPhase 2182015-02-23Thyroid DiseasesLEVOTHYROXINE, LIOTHYRONINEIts record names the diseaseClinicalTrials.gov
NCT04782856Energy Metabolism in Thyroidectomized PatientsPhase 2132024-06-14Thyroid Goiter, Hypothyroidism, Thyroid CancerLEVOTHYROXINE, LIOTHYRONINEIts record names the diseaseClinicalTrials.gov

1 to 10 of 59

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Comparisons in its trials17

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Armour® Thyroid vs Levothyroxine: deaths from any cause1 of 1411 of 143284NCT04124705Trial comparisons
Armour® Thyroid vs Levothyroxine: serious adverse events4 of 1417 of 143284NCT04124705Trial comparisons
Radioiodine vs Control: deaths from any cause1 of 510 of 50101NCT03880578Trial comparisons
Radioiodine vs Control: serious adverse events0 of 510 of 50101NCT03880578Trial comparisons
Treatment Period: Tirosint Capsules vs Run-in Period: LT4 Tablets: deaths from any cause0 of 470 of 4794NCT03094416Trial comparisons
Treatment Period: Tirosint Capsules vs Run-in Period: LT4 Tablets: serious adverse events1 of 472 of 4794NCT03094416Trial comparisons
All Participants vs Participants Who Entered Maintenance Period: Proportion of Participants With Normalized TSH at End of Maintenance Period31 of 4631 of 4288NCT05823012Trial comparisons
All Participants vs Participants Who Entered the Maintenance Period: Proportion of Participants With Normalized TSH Throughout the Maintenance Period27 of 4627 of 4288NCT05823012Trial comparisons
2 Tablet Increase vs 3 Tablet Increase: the Participants in Each Arm Who Required Levothyroxine Dose Adjustments (Either Increased or Decreased) Occurred to Maintain a Euthyroid State10 of 2516 of 2348NCT00230802Trial comparisons
2 Tablet Increase vs 3 Tablet Increase: Proportion of Subjects With Abnormal Thyroid Stimulating Hormone Values When Following an Every 4 Week Monitoring Schedule During Pregnancy.25 of 2523 of 2348NCT00230802Trial comparisons

1 to 10 of 17

See all 17 comparisons in its trials

Papers from its trials42

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
21586104RESULT1PubMed
21424182RESULT1PubMed
20463094RESULT1PubMed
19682539RESULT1PubMed
18407156RESULT1PubMed
16984248RESULT1PubMed
14749496RESULT1PubMed
11172193RESULT1PubMed
42492995DERIVED1PubMed
41210509DERIVED1PubMed

1 to 10 of 42

See all 42 papers from its trials

Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005420

GET https://conductscience.org/api/diseases/v1/MONDO_0005420/trials?page=2

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