Disease · MONDO_0005649

appendicitis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. appendicitis. Diseases, record MONDO_0005649. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005649

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: appendicitis; Open Targets
Open Targets ID: MONDO_0005649; Open Targets
Other names: acute appendicitis, acute appendicitis with generalized peritonitis, acute appendicitis with generalized peritonitis (disorder), acute appendicitis with peritoneal abscess, acute appendicitis with peritoneal abscess (disorder), inflammation of vermiform appendix, vermiform appendix inflammation; Open Targets
Disease Ontology: DOID:8337; Disease Ontology
MeSH: D001064; MeSH
NCI Thesaurus: C35145; NCI Thesaurus
Highest stage of its drugs: Approval, for 3 of its 38 drugs, from DailyMed and TTD; Open Targets

Drugs38

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
PIPERACILLIN SODIUM	CHEMBL1200820	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
TAZOBACTAM SODIUM	CHEMBL1439	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
TECHNETIUM TC 99M FANOLESOMAB	CHEMBL2107902	Antibody	Approval	TTD	1	0	0	Drugs and targets
METRONIDAZOLE	CHEMBL137	Small molecule	Phase 3	ClinicalTrials.gov	15	15	15	Drugs and targets
CEFTRIAXONE	CHEMBL161	Small molecule	Phase 3	ClinicalTrials.gov	6	6	6	Drugs and targets
LEVOFLOXACIN	CHEMBL5315124	Small molecule	Phase 3	ClinicalTrials.gov	5	5	5	Drugs and targets
AMOXICILLIN/CLAVULANIC ACID	CHEMBL1697738	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
DEXMEDETOMIDINE	CHEMBL778	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
FENTANYL	CHEMBL596	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
KETOROLAC TROMETHAMINE	CHEMBL1201124	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets

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Targets12

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
OPRM1	Mu-type opioid receptor	4	Mu opioid receptor agonist	Phase 3	https://conductscience.org/library/genes/4988	Drugs and targets
PTGS1	Cyclooxygenase	3	Cyclooxygenase inhibitor	Phase 3	https://conductscience.org/library/genes/5742	Drugs and targets
PTGS2	Cyclooxygenase	3	Cyclooxygenase inhibitor	Phase 3	https://conductscience.org/library/genes/5743	Drugs and targets
ADRA2A	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Phase 3	https://conductscience.org/library/genes/150	Drugs and targets
ADRA2B	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Phase 3	https://conductscience.org/library/genes/151	Drugs and targets
ADRA2C	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Phase 3	https://conductscience.org/library/genes/152	Drugs and targets
CSF2RA	Granulocyte-macrophage colony-stimulating factor receptor	1	Granulocyte-macrophage colony-stimulating factor receptor agonist	Phase 2	https://conductscience.org/library/genes/1438	Drugs and targets
CSF2RB	Granulocyte-macrophage colony-stimulating factor receptor	1	Granulocyte-macrophage colony-stimulating factor receptor agonist	Phase 2	https://conductscience.org/library/genes/1439	Drugs and targets
CSF3R	Granulocyte colony-stimulating factor receptor	1	Granulocyte colony stimulating factor receptor agonist	Phase 2	https://conductscience.org/library/genes/1441	Drugs and targets
FAAH	Fatty-acid amide hydrolase 1	1	Anandamide amidohydrolase inhibitor	Phase 1/2	https://conductscience.org/library/genes/2166	Drugs and targets

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Trials30

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02800785	The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial	Not applicable	1,552	2023-04-18	Appendicitis	CEFAZOLIN, CEFOTAXIME, CEFOXITIN, CEFTRIAXONE, CEFUROXIME, CIPROFLOXACIN, ERTAPENEM, LEVOFLOXACIN, METRONIDAZOLE, MOXIFLOXACIN, TICARCILLIN, TIGECYCLINE	Its record names the disease	ClinicalTrials.gov
NCT01022567	Appendicectomy Versus Antibiotics in the Treatment of Acute Uncomplicated Appendicitis	Not applicable	530	2017-02-23	Acute Appendicitis	ERTAPENEM	Its record names the disease	ClinicalTrials.gov
NCT05470517	Antibiotic Instillation in Appendicitis	Phase 2	190	2025-03-13	Complicated Appendicitis, Acute Appendicitis	CEFTRIAXONE	Its record names the disease	ClinicalTrials.gov
NCT02189668	Non-operative Management of Pediatric Appendicitis With an Appendicoltih	Not applicable	14	2018-04-17	Appendicitis	AMOXICILLIN, PIPERACILLIN, TAZOBACTAM	Its record names the disease	ClinicalTrials.gov
NCT03688295	The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis)	Phase 3	1,476		Complicated Acute Appendicitis	CEFTRIAXONE, LEVOFLOXACIN, METRONIDAZOLE	Its record names the disease	ClinicalTrials.gov
NCT07587450	Efficacy of Non Operative Treatment With Amoxicillin/Clavulanic Acid Versus Surgical Treatment in Acute Uncomplicated Appendicitis in Children	Phase 3	724		Acute Uncomplicated Appendicitis	AMOXICILLIN/CLAVULANIC ACID	Its record names the disease	ClinicalTrials.gov
NCT03236961	Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis	Not applicable	552		Acute Appendicitis	ERTAPENEM, LEVOFLOXACIN, METRONIDAZOLE, MOXIFLOXACIN	Its record names the disease	ClinicalTrials.gov
NCT06210269	Oral Antibiotic Outpatient Therapy vs. Placebo in the Treatment of Uncomplicated Acute Appendicitis	Not applicable	498		Uncomplicated Acute Appendicitis	MOXIFLOXACIN	Its record names the disease	ClinicalTrials.gov
NCT06160778	Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain	Phase 3	495		Acute Pain, Abdomen, Acute, Abdominal Pain, Appendicitis, Emergencies, Child, Only	KETOROLAC TROMETHAMINE, MORPHINE SULFATE	Its record names the disease	ClinicalTrials.gov
NCT00469430	Study of Conservative Versus Surgical Treatment of Appendicitis	Phase 2	360		Appendicitis	CEFOTAXIME, METRONIDAZOLE	Its record names the disease	ClinicalTrials.gov

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Comparisons in its trials13

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Antibiotics Therapy Arm vs Appendectomy Arm: Rates of Participants With Appendiceal Cancer	4 of 776	6 of 776	1,552	NCT02800785	Trial comparisons
Antibiotics Therapy Arm vs Appendectomy Arm: Total Number of Patients Who Had Resolution of Appendicitis Symptoms at 30 Days	462 of 676	466 of 663	1,339	NCT02800785	Trial comparisons
Antibiotics Therapy Arm vs Appendectomy Arm: Number of Participants With at Least One Complications From Treatment	37 of 676	21 of 656	1,332	NCT02800785	Trial comparisons
Antibiotics Therapy Arm vs Appendectomy Arm: deaths from any cause	0 of 676	0 of 656	1,332	NCT02800785	Trial comparisons
Antibiotics Therapy Arm vs Appendectomy Arm: serious adverse events	19 of 676	19 of 656	1,332	NCT02800785	Trial comparisons
Antibiotics Therapy Arm vs Appendectomy Arm: Rate of Participants With Perforated Appendicitis	59 of 185	99 of 621	806	NCT02800785	Trial comparisons
Appendectomy vs Antibiotic Therapy: serious adverse events	0 of 273	0 of 257	530	NCT01022567	Trial comparisons
Standard of Care and Antibiotic Instillation (Arm B) vs Standard of Care (Arm A): deaths from any cause	0 of 16	0 of 16	32	NCT05470517	Trial comparisons
Standard of Care and Antibiotic Instillation (Arm B) vs Standard of Care (Arm A): serious adverse events	0 of 16	0 of 16	32	NCT05470517	Trial comparisons
Non-operative vs Surgery: Number of Participants With Complicated Appendicitis	0 of 5	6 of 9	14	NCT02189668	Trial comparisons

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Papers from its trials34

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
31040341	RESULT	1	PubMed
27437029	RESULT	1	PubMed
27018085	RESULT	1	PubMed
26080338	RESULT	1	PubMed
41711118	DERIVED	1	PubMed
41563747	DERIVED	1	PubMed
41202087	DERIVED	1	PubMed
40741675	DERIVED	2	PubMed
39636024	DERIVED	1	PubMed
39160081	DERIVED	1	PubMed

1 to 10 of 34

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005649

GET https://conductscience.org/api/diseases/v1/MONDO_0005649/drugs?page=2

API reference For AI assistants