Disease · MONDO_0006625
altitude sickness
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. altitude sickness. Diseases, record MONDO_0006625. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0006625
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Other names
- AMS, acute mountain sickness, altitude hypoxia, altitude illness, hypobaropathy, mountain sickness, soroche, the altitude bends
- Open Targets
Drugs6
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| ACETAZOLAMIDE | CHEMBL20 | Small molecule | Approval | DailyMed | 26 | 5 | 5 | Drugs and targets |
| AES-103 | CHEMBL185885 | Small molecule | Phase 1/2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| DEXAMETHASONE | CHEMBL384467 | Small molecule | Phase 1 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| CARBON DIOXIDE | CHEMBL1231871 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| IBUPROFEN | CHEMBL521 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| METOCLOPRAMIDE | CHEMBL86 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
Targets10
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| CA1 | Carbonic anhydrase 1 | 1 | Carbonic anhydrase I inhibitor | Approval | https://conductscience.org/library/genes/759 | Drugs and targets |
| CA12 | Carbonic anhydrase 12 | 1 | Carbonic anhydrase XII inhibitor | Approval | https://conductscience.org/library/genes/771 | Drugs and targets |
| CA2 | Carbonic anhydrase 2 | 1 | Carbonic anhydrase II inhibitor | Approval | https://conductscience.org/library/genes/760 | Drugs and targets |
| CA4 | Carbonic anhydrase 4 | 1 | Carbonic anhydrase IV inhibitor | Approval | https://conductscience.org/library/genes/762 | Drugs and targets |
| DRD2 | D(2) dopamine receptor | 1 | Dopamine D2 receptor antagonist | Unknown | https://conductscience.org/library/genes/1813 | Drugs and targets |
| HTR3A | 5-hydroxytryptamine receptor 3A | 1 | Serotonin 3a (5-HT3a) receptor antagonist | Unknown | https://conductscience.org/library/genes/3359 | Drugs and targets |
| HTR4 | 5-hydroxytryptamine receptor 4 | 1 | Serotonin 4 (5-HT4) receptor agonist | Unknown | https://conductscience.org/library/genes/3360 | Drugs and targets |
| NR3C1 | Glucocorticoid receptor | 1 | Glucocorticoid receptor agonist | Phase 1 | https://conductscience.org/library/genes/2908 | Drugs and targets |
| PTGS1 | Cyclooxygenase | 1 | Cyclooxygenase inhibitor | Unknown | https://conductscience.org/library/genes/5742 | Drugs and targets |
| PTGS2 | Cyclooxygenase | 1 | Cyclooxygenase inhibitor | Unknown | https://conductscience.org/library/genes/5743 | Drugs and targets |
Trials9
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT01288781 | Intracranial Pressure in Experimental Models of Headache | Not applicable | 23 | 2011-12-26 | High Altitude Headache | ACETAZOLAMIDE | Its record names the disease | ClinicalTrials.gov |
| NCT01871142 | Evaluation of the Attenuation by Aes-103 of Hypoxia Mediated Decrements in Endurance Exercise Performance | Phase 1/2 | 12 | 2014-10-24 | Hypoxia | AES-103 | Its record names the disease | ClinicalTrials.gov |
| NCT01522326 | Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness | Not applicable | 300 | Acute Mountain Sickness, High Altitude Headache | IBUPROFEN, METOCLOPRAMIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT04915365 | Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders With COPD Traveling to High Altitude | Phase 3 | 100 | Right Heart Function, Chronic Obstructive Pulmonary Disease, Altitude Sickness | ACETAZOLAMIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT03536520 | Effect of Acetazolamide on Visuo-motor Learning in Lowlanders Older Than 40 Years at Altitude | Phase 4 | 59 | Altitude Hypoxia | ACETAZOLAMIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT05798416 | Effect of Inhalation of Low Dose CO2 on Exercise Performance at High Altitude | Not applicable | 28 | High Altitude, Inhalation; Gas, Acute Mountain Sickness | CARBON DIOXIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT07517068 | The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude | Early phase 1 | 19 | Hypoxemia, Acute Mountain Sickness (AMS), Inflammation, Immune Response | ACETAZOLAMIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT03341676 | Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE) | Phase 1 | 10 | High Altitude Cerebral Edema | DEXAMETHASONE | Its record names the disease | ClinicalTrials.gov | |
| NCT03525561 | Acetazolamide and Exercise Performance at Altitude | Early phase 1 | 10 | Hypoxia, Exercise Performance, Cognitive Function, Dexterity | ACETAZOLAMIDE | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials1
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial |
|---|---|---|---|---|
| Acetazolamide vs Placebo: serious adverse events | 0 of 11 | 0 of 12 | 23 | NCT01288781 |
Source Trial comparisons
Papers from its trials4
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0006625
GET https://conductscience.org/api/diseases/v1/MONDO_0006625/drugs