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Paper23948585

Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes.

Kolwicz SC and 2 others. Circ Res, 2013. Cited by 680 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Papers, record 23948585. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/23948585

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes.
PubMed
Journal
Circ Res
PubMed
Year
2013
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
PubMed
Citations, by iCite
680
iCite
Relative citation ratio, by iCite
20.2
iCite
Revised in PubMed
2022-03-16
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Kolwicz SC JrStephen C
2Purohit SSuneet
3Tian RRong

Source PubMed

Topics26

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Energy MetabolismMajor topic
Myocardial ContractionMajor topic
MyocardiumMajor topic
Myocytes, CardiacMajor topic
Adaptation, Physiological
Adenosine Triphosphate
Animals
Apoptosis
Autophagy
Cardiomegaly
Cell Survival
Diabetes Mellitus
Diet
Fatty Acids
Heart
Heart Failure
Humans
Insulin Resistance
Metabolic Networks and Pathways
Mitochondria, Heart
Obesity
Phosphorylation
Protein Processing, Post-Translational
Randomized Controlled Trials as Topic
Substrate Specificity
TOR Serine-Threonine Kinases

Source PubMed

Grants7

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 HL067970NHLBI NIH HHSUnited StatesR01HL067970PubMed and NIHNIH RePORTER
R01 HL088634NHLBI NIH HHSUnited StatesR01HL088634PubMed and NIHNIH RePORTER
R01 HL110349NHLBI NIH HHSUnited StatesR01HL110349PubMed and NIHNIH RePORTER
HL088634NHLBI NIH HHSUnited StatesR01HL088634PubMed and NIHNIH RePORTER
R01 HL059246NHLBI NIH HHSUnited StatesR01HL059246PubMed and NIHNIH RePORTER
HL0962842NHLBI NIH HHSUnited StatesPubMedPubMed
HL110349NHLBI NIH HHSUnited StatesR01HL110349PubMed and NIHNIH RePORTER

Trials2

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's recordSource
NCT05772442Cardiac Transplant Metabolomics With and Without RejectionBackgroundClinicalTrials.gov
NCT06398964Effects of 2-week Ketosis on the Heart's Ketone Body Consumption, Utilization, and Energetic Efficiency in Patients With Chronic Heart FailureBackgroundClinicalTrials.gov

References223

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
115,047,624Hexosamine pathway is responsible for inhibition by diabetes of phenylephrine-induced inotropy.Diabetes2004https://conductscience.org/library/papers/15047624PubMed
214,757,696Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase.Circulation2004https://conductscience.org/library/papers/14757696PubMed
311,781,357The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.J Clin Invest2002https://conductscience.org/library/papers/11781357PubMed
416,365,092Branched-chain amino acid catabolism in exercise and liver disease.J Nutr2006https://conductscience.org/library/papers/16365092PubMed
518,515,784Ceramide is a cardiotoxin in lipotoxic cardiomyopathy.J Lipid Res2008https://conductscience.org/library/papers/18515784PubMed
620,729,341Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation.Cardiovasc Res2011https://conductscience.org/library/papers/20729341PubMed
719,815,124Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging.J Am Coll Cardiol2009https://conductscience.org/library/papers/19815124PubMed
812,798,436The PPARgamma-activator rosiglitazone does not alter remodeling but increases mortality in rats post-myocardial infarction.Cardiovasc Res2003https://conductscience.org/library/papers/12798436PubMed
917,623,815Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.Diabetes2007https://conductscience.org/library/papers/17623815PubMed
1011,018,072Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis.J Clin Invest2000https://conductscience.org/library/papers/11018072PubMed
1123,487,436Long-chain monounsaturated Fatty acids and incidence of congestive heart failure in 2 prospective cohorts.Circulation2013https://conductscience.org/library/papers/23487436PubMed
1212,163,031Up-regulation of SREBP-1c and lipogenic genes in skeletal muscles after exercise training.Biochem Biophys Res Commun2002https://conductscience.org/library/papers/12163031PubMed
1311,410,919Nerve conduction changes in patients with mitochondrial diseases treated with dichloroacetate.Muscle Nerve2001https://conductscience.org/library/papers/11410919PubMed
1421,143,620Metformin improves cardiac function in rats via activation of AMP-activated protein kinase.Clin Exp Pharmacol Physiol2011https://conductscience.org/library/papers/21143620PubMed
1517,174,230Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure.J Card Fail2006https://conductscience.org/library/papers/17174230PubMed
168,901,462Regulation of and intervention into the oxidative pentose phosphate pathway and adenine nucleotide metabolism in the heart.Mol Cell Biochem1996https://conductscience.org/library/papers/8901462PubMed
1720,529,848Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment.J Biol Chem2010https://conductscience.org/library/papers/20529848PubMed
1814,747,227Cardiac abnormalities in diabetic patients with neuropathy: effects of aldose reductase inhibitor administration.Diabetes Care2004https://conductscience.org/library/papers/14747227PubMed
1911,988,641Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth.Heart Fail Rev2002https://conductscience.org/library/papers/11988641PubMed
2015,817,886Adenovirus-mediated overexpression of O-GlcNAcase improves contractile function in the diabetic heart.Circ Res2005https://conductscience.org/library/papers/15817886PubMed

See all 223 references

Cited by494

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 680 citations.

PMIDTitleJournalYearIn PapersSource
42,972,381NAMPT-dependent NAD+ decline drives energy metabolism changes in aging-related atrial fibrillation.BMC Med2026https://conductscience.org/library/papers/42972381PubMed
42,939,835Redox Phenotyping of the Donor Heart: A New Paradigm for Precision Heart Transplantation.Antioxidants (Basel)2026https://conductscience.org/library/papers/42939835PubMed
42,871,478Glycemia reprograms substrate transport and shapes divergent stress responses in differentiating H9c2 cells.Cell Stress2026https://conductscience.org/library/papers/42871478PubMed
42,859,702Glutamine Metabolism in Cardiac Hypertrophy.Rev Cardiovasc Med2026https://conductscience.org/library/papers/42859702PubMed
42,849,439Immunoregulatory gene GIMAP6 suppresses lethal atherosclerotic vasculopathy and ischemic heart failure.Cell2026https://conductscience.org/library/papers/42849439PubMed
42,701,686Acetyl-CoA synthetase 2 maintains cytosolic acetyl-CoA homeostasis to preserve mitochondrial integrity and attenuate cardiac dysfunction under chronic β-adrenergic stress.J Mol Cell Cardiol Plus2026https://conductscience.org/library/papers/42701686PubMed
42,701,407FASN-mediated de novo lipogenesis promotes ceramide accumulation and myocardial damage in arrhythmogenic cardiomyopathy.iScience2026https://conductscience.org/library/papers/42701407PubMed
42,676,526Tricholoma matsutake polypeptide modulates cardiac metabolism and restores autophagic flux to mitigate doxorubicin-induced senescence.Front Pharmacol2026https://conductscience.org/library/papers/42676526PubMed
42,651,726Maternal Exercise and Offspring Cardiac Regenerative Potential: Roles of Apelin and α-Ketoglutarate.Biology (Basel)2026https://conductscience.org/library/papers/42651726PubMed
42,644,116Myocardial Metabolism and Postoperative Risk Stratification in Cardiac Surgery: A Narrative Review and Conceptual Framework.Cureus2026https://conductscience.org/library/papers/42644116PubMed
42,642,787Aging-Related Myocardial Susceptibility Lowers Cardiac Tolerance to Chronic Intermittent Hypoxia Through Dynamin-Related Protein 1-Associated Mitochondrial Vulnerability.Aging Cell2026https://conductscience.org/library/papers/42642787PubMed
42,638,823Targeting SRPK3 Attenuates Cardiac Hypertrophy and Heart Failure by Improving Mitochondrial Bioenergetics through mRNA Splicing and Decay.Research (Wash D C)2026https://conductscience.org/library/papers/42638823PubMed
42,630,156Integrated analysis of MYH6, MYH7, and MYH7B expression and their associated microRNAs in human end-stage heart failure.Front Cardiovasc Med2026https://conductscience.org/library/papers/42630156PubMed
42,602,298Research progress on metabolic abnormalities in myocardial hypertrophy.Front Cardiovasc Med2026https://conductscience.org/library/papers/42602298PubMed
42,565,878Metabolic fatty acid substrates enhance the structural and mechanical performance of human-induced pluripotent stem cell-derived cardiomyocytes.Cell Mol Life Sci2026https://conductscience.org/library/papers/42565878PubMed
42,547,868Association of the triglyceride-glucose index with subclinical left ventricular dysfunction in type 2 diabetes mellitus: mediation by myocardial energetic efficiency and resting perfusion.Cardiovasc Diabetol2026https://conductscience.org/library/papers/42547868PubMed
42,523,454Integrated Myocardial and Plasma Lipidome Across the Human Obesity-Heart Failure Spectrum.Res Sq2026https://conductscience.org/library/papers/42523454PubMed
42,510,102Prognostic Value of Dynamic FDG PET-Derived Myocardial Glucose Metabolism in Ischemic Cardiomyopathy with Supportive External Gene-Expression Analysis.Diagnostics (Basel)2026https://conductscience.org/library/papers/42510102PubMed
42,474,977Effects of different intensity endurance training on atrial fibrillation in rats.Mol Cell Biochem2026https://conductscience.org/library/papers/42474977PubMed
42,439,641Cardiac Metabolism in Healthy, Senescent and Diseased States.Cells2026https://conductscience.org/library/papers/42439641PubMed

See all 494 cited by

Genes24

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ACACB32PubTator's text mininghttps://conductscience.org/library/genes/32NCBI Gene
ALDH7A1501PubTator's text mininghttps://conductscience.org/library/genes/501NCBI Gene
BCKDK10,295PubTator's text mininghttps://conductscience.org/library/genes/10295NCBI Gene
CPT1B1,375PubTator's text mininghttps://conductscience.org/library/genes/1375NCBI Gene
ESRRA2,101PubTator's text mininghttps://conductscience.org/library/genes/2101NCBI Gene
FOXO12,308PubTator's text mininghttps://conductscience.org/library/genes/2308NCBI Gene
G6PD2,539PubTator's text mininghttps://conductscience.org/library/genes/2539NCBI Gene
GFPT12,673PubTator's text mininghttps://conductscience.org/library/genes/2673NCBI Gene
GLP1R2,740PubTator's text mininghttps://conductscience.org/library/genes/2740NCBI Gene
GYS12,997PubTator's text mininghttps://conductscience.org/library/genes/2997NCBI Gene
HIF1A3,091PubTator's text mininghttps://conductscience.org/library/genes/3091NCBI Gene
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene
MLYCD23,417PubTator's text mininghttps://conductscience.org/library/genes/23417NCBI Gene
MTOR2,475PubTator's text mininghttps://conductscience.org/library/genes/2475NCBI Gene
OGT8,473PubTator's text mininghttps://conductscience.org/library/genes/8473NCBI Gene
PDK45,166PubTator's text mininghttps://conductscience.org/library/genes/5166NCBI Gene
PDP154,704PubTator's text mininghttps://conductscience.org/library/genes/54704NCBI Gene
PIK3C35,289PubTator's text mininghttps://conductscience.org/library/genes/5289NCBI Gene
PPARA5,465PubTator's text mininghttps://conductscience.org/library/genes/5465NCBI Gene
PPARG5,468PubTator's text mininghttps://conductscience.org/library/genes/5468NCBI Gene

See all 24 genes

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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