Disease · EFO_0009842

respiratory depression

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. respiratory depression. Diseases, record EFO_0009842. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_0009842

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: respiratory depression; Open Targets
Open Targets ID: EFO_0009842; Open Targets
NCI Thesaurus: C116314; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 2 of its 12 drugs, from ClinicalTrials.gov and TTD; Open Targets

Drugs12

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
NALOXONE	CHEMBL80	Small molecule	Phase 3	ClinicalTrials.gov and TTD	2	1	1	Drugs and targets
NALMEFENE	CHEMBL982	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
NEOSTIGMINE	CHEMBL278020	Small molecule	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
FENTANYL	CHEMBL596	Small molecule	Phase 1	ClinicalTrials.gov	3	3	3	Drugs and targets
OXYCODONE	CHEMBL656	Small molecule	Phase 1	ClinicalTrials.gov	2	2	2	Drugs and targets
BUPRENORPHINE	CHEMBL511142	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
MIDAZOLAM	CHEMBL655	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
PAROXETINE	CHEMBL490	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
QUETIAPINE	CHEMBL716	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
PROPOFOL	CHEMBL526	Small molecule	Unknown	ClinicalTrials.gov	3	3	3	Drugs and targets

1 to 10 of 12

See all 12 drugs

Targets31

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
OPRM1	Mu-type opioid receptor	6	Mu opioid receptor agonist; Mu opioid receptor antagonist; Opioid receptors; mu/kappa/delta antagonist	Phase 3	https://conductscience.org/library/genes/4988	Drugs and targets
OPRK1	Kappa-type opioid receptor	3	Kappa opioid receptor agonist; Kappa opioid receptor partial agonist; Opioid receptors; mu/kappa/delta antagonist	Phase 3	https://conductscience.org/library/genes/4986	Drugs and targets
GABRA1	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 1	https://conductscience.org/library/genes/2554	Drugs and targets
GABRA2	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 1	https://conductscience.org/library/genes/2555	Drugs and targets
GABRA3	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 1	https://conductscience.org/library/genes/2556	Drugs and targets
GABRA4	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 1	https://conductscience.org/library/genes/2557	Drugs and targets
GABRA5	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 1	https://conductscience.org/library/genes/2558	Drugs and targets
GABRA6	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 1	https://conductscience.org/library/genes/2559	Drugs and targets
GABRB1	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 1	https://conductscience.org/library/genes/2560	Drugs and targets
GABRB2	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 1	https://conductscience.org/library/genes/2561	Drugs and targets

1 to 10 of 31

See all 31 targets

Trials10

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT04310579	Clinical Study to Investigate the Effect of the Combination of Psychotropic Drugs and an Opioid on Ventilation	Phase 1	55	2024-05-21	Hypercapnia, Ventilatory Depression	MIDAZOLAM, OXYCODONE, PAROXETINE, QUETIAPINE	Its record names the disease	ClinicalTrials.gov
NCT05280743	Precision Opioid Care After Cesarean Delivery (PRECISE-CD)		341		Cesarean Section Complications, Opioid Use	OXYCODONE	Its record names the disease	ClinicalTrials.gov
NCT00832013	Safe Administration of Propofol for Sedation in Children	Not applicable	120		Sedation	PROPOFOL	Its record names the disease	ClinicalTrials.gov
NCT05473949	Ketofol Versus Propofol for Sedation in Cholangiopancreatography for ASA III and ASA IV Patients.	Not applicable	102		Anesthesia	KETAMINE, PROPOFOL	Its record names the disease	ClinicalTrials.gov
NCT07097441	To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU.	Phase 1/2	100		Tachycardia, Hypertension, Hypoxia, Hyperventilation, Residual Paralysis, Post Anesthesia	NEOSTIGMINE	Its record names the disease	ClinicalTrials.gov
NCT06060626	Optimization of Sedation Protocol for Endoscopic Procedures Using Impedance Ventilation Monitor.	Not applicable	50		Sedation Complication, Ventilatory Depression	FENTANYL, PROPOFOL	Its record names the disease	ClinicalTrials.gov
NCT02819661	Respiratory Depression in Women With BMI≥30 Underwent Spinal Anesthesia With Intrathecal Morphine in Elective C-section	Not applicable	30		Respiratory Depression	MORPHINE	Its record names the disease	ClinicalTrials.gov
NCT04786275	Evaluation of the Nociception Guided by NoL Index and PK of Fentanyl in Pediatric Patients Under General Anesthesia		25		Pain, Anesthesia, Pediatric ALL	FENTANYL	Its record names the disease	ClinicalTrials.gov
NCT03747341	Buprenorphine-Fentanyl Interaction Study	Phase 1	22		Healthy, Opioid Use	BUPRENORPHINE, FENTANYL	Its record names the disease	ClinicalTrials.gov
NCT06408714	Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose	Phase 3	0		Opioid Overdose, Opiate Overdose	NALMEFENE, NALOXONE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials23

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
37139057	RESULT	1	PubMed
35085249	RESULT	1	PubMed
34667360	RESULT	1	PubMed
30573962	RESULT	1	PubMed
29261883	RESULT	1	PubMed
28337439	RESULT	1	PubMed
25037938	RESULT	1	PubMed
23372884	RESULT	1	PubMed
22091288	RESULT	1	PubMed
21237532	RESULT	1	PubMed

1 to 10 of 23

See all 23 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_0009842

GET https://conductscience.org/api/diseases/v1/EFO_0009842/targets?page=2

API reference For AI assistants