Disease · EFO_1001412
renal colic
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. renal colic. Diseases, record EFO_1001412. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_1001412
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
Drugs27
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| MORPHINE | CHEMBL70 | Small molecule | Phase 3 | ClinicalTrials.gov | 6 | 6 | 6 | Drugs and targets |
| ACETAMINOPHEN | CHEMBL112 | Small molecule | Phase 3 | ClinicalTrials.gov | 4 | 4 | 4 | Drugs and targets |
| DESMOPRESSIN | CHEMBL1429 | Protein | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| KETAMINE | CHEMBL742 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| PIROXICAM | CHEMBL527 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| DEXAMETHASONE | CHEMBL384467 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| DRONABINOL | CHEMBL465 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| INDOMETHACIN | CHEMBL6 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| TERBUTALINE | CHEMBL1760 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| KETOROLAC TROMETHAMINE | CHEMBL1201124 | Small molecule | Phase 2/3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
1 to 10 of 27
See all 27 drugsTargets62
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| PTGS1 | Cyclooxygenase | 10 | Cyclooxygenase inhibitor | Phase 3 | https://conductscience.org/library/genes/5742 | Drugs and targets |
| PTGS2 | Cyclooxygenase | 10 | Cyclooxygenase inhibitor | Phase 3 | https://conductscience.org/library/genes/5743 | Drugs and targets |
| OPRM1 | Mu-type opioid receptor | 3 | Mu opioid receptor agonist | Phase 3 | https://conductscience.org/library/genes/4988 | Drugs and targets |
| ADORA1 | Adenosine receptor | 1 | Adenosine receptor antagonist | Phase 2 | https://conductscience.org/library/genes/134 | Drugs and targets |
| ADORA2A | Adenosine receptor | 1 | Adenosine receptor antagonist | Phase 2 | https://conductscience.org/library/genes/135 | Drugs and targets |
| ADORA2B | Adenosine receptor | 1 | Adenosine receptor antagonist | Phase 2 | https://conductscience.org/library/genes/136 | Drugs and targets |
| ADORA3 | Adenosine receptor | 1 | Adenosine receptor antagonist | Phase 2 | https://conductscience.org/library/genes/140 | Drugs and targets |
| ADRB2 | Beta-2 adrenergic receptor | 1 | Beta-2 adrenergic receptor agonist | Phase 3 | https://conductscience.org/library/genes/154 | Drugs and targets |
| AVPR1A | Vasopressin receptor | 1 | Vasopressin receptor agonist | Phase 3 | https://conductscience.org/library/genes/552 | Drugs and targets |
| AVPR1B | Vasopressin receptor | 1 | Vasopressin receptor agonist | Phase 3 | https://conductscience.org/library/genes/553 | Drugs and targets |
1 to 10 of 62
See all 62 targetsTrials23
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 2 more are not shown, since the checks do not confirm them.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT03617289 | Efficacy of Magnesium Sulfate on Reducing Renal Colic in the Emergency Department | Not applicable | 37 | 2023-03-24 | Renal Colic | MAGNESIUM SULFATE | Its record names the disease | ClinicalTrials.gov |
| NCT06345716 | Paracetamol-Tramadol and Paracetamol-caffeine Versus Placebo in the Emergency Discharge Treatment of Renal Colic | Phase 2 | 1,500 | Renal Colic | ACETAMINOPHEN, CAFFEINE, TRAMADOL | Its record names the disease | ClinicalTrials.gov | |
| NCT02304783 | Oral NSAI Versus Paracetamol or Placebo as a Second Line Treatment for Renal Colics | Phase 3 | 1,400 | Renal Colic | ACETAMINOPHEN, PIROXICAM | Its record names the disease | ClinicalTrials.gov | |
| NCT05653401 | Treatment of Renal Colic in the Emergency Department: Comparison Between Magnesium Sulfate and Lidocaine. | Phase 2 | 800 | Renal Colic | DICLOFENAC, MAGNESIUM SULFATE | Its record names the disease | ClinicalTrials.gov | |
| NCT03199924 | Treatment of Renal Colic in the Emergency Departement (ED). | Phase 2 | 600 | Renal Colic | DICLOFENAC, LIDOCAINE, MAGNESIUM SULFATE | Its record names the disease | ClinicalTrials.gov | |
| NCT06342648 | Intracutaneous Sterile Water and Diclofenac Sodium Injections in Renal Colic | Not applicable | 570 | Renal Colic | DICLOFENAC SODIUM, WATER | Its record names the disease | ClinicalTrials.gov | |
| NCT05722782 | Oral NSAI Versus Acetaminophen or Placebo as a Discharge Treatment of Non Complicated Renal Colics | Phase 2 | 500 | Renal Colic | ACETAMINOPHEN, PIROXICAM | Its record names the disease | ClinicalTrials.gov | |
| NCT06980727 | Comparative Efficacy of IV Dexamethasone vs. Nebulized Terbutaline for Renal Colic Pain in the ED | Phase 3 | 500 | Renal Colic | DEXAMETHASONE, TERBUTALINE | Its record names the disease | ClinicalTrials.gov | |
| NCT07536594 | Relief Efficacy of Lidocaine Versus Morphine for Acute Renal Colic in the Emergency Department | Not applicable | 250 | Renal Colic, Kidney Stones, Urolithiasis, Hypocitraturia, Opioid Use During Medical Care | LIDOCAINE, MORPHINE | Its record names the disease | ClinicalTrials.gov | |
| NCT02781415 | Acupuncture Versus Titrated Morphine in Patients With Renal Colic | Phase 3 | 200 | Renal Colic | MORPHINE | Its record names the disease | ClinicalTrials.gov |
1 to 10 of 23
See all 23 trialsComparisons in its trials1
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial |
|---|---|---|---|---|
| Treatment vs Placebo: serious adverse events | 0 of 18 | 0 of 19 | 37 | NCT03617289 |
Source Trial comparisons
Papers from its trials16
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/EFO_1001412
GET https://conductscience.org/api/diseases/v1/EFO_1001412/drugs?page=2