Disease · HP_0000023

Inguinal hernia

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. Inguinal hernia. Diseases, record HP_0000023. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0000023

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: Inguinal hernia; Open Targets
Open Targets ID: HP_0000023; Open Targets
MeSH: D006552; MeSH
Highest stage of its drugs: Phase 3, for 6 of its 18 drugs, from ClinicalTrials.gov; Open Targets

Drugs18

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
DEXMEDETOMIDINE	CHEMBL778	Small molecule	Phase 3	ClinicalTrials.gov	4	4	4	Drugs and targets
SEVOFLURANE	CHEMBL1200694	Small molecule	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
ACETAMINOPHEN	CHEMBL112	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
BUPIVACAINE HYDROCHLORIDE	CHEMBL1200396	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
IBUPROFEN	CHEMBL521	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
OXYCODONE	CHEMBL656	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
FENTANYL	CHEMBL596	Small molecule	Phase 2/3	ClinicalTrials.gov	2	2	2	Drugs and targets
LEVOBUPIVACAINE	CHEMBL1201193	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
BUPIVACAINE	CHEMBL1098	Small molecule	Phase 2	ClinicalTrials.gov	7	7	5	Drugs and targets
CHLOROPROCAINE	CHEMBL1179047	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets

1 to 10 of 18

See all 18 drugs

Targets48

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
SCN4A	Sodium channel alpha subunit	7	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6329	Drugs and targets
SCN10A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6336	Drugs and targets
SCN11A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/11280	Drugs and targets
SCN1A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6323	Drugs and targets
SCN2A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6326	Drugs and targets
SCN3A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6328	Drugs and targets
SCN5A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6331	Drugs and targets
SCN7A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6332	Drugs and targets
SCN8A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6334	Drugs and targets
SCN9A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6335	Drugs and targets

1 to 10 of 48

See all 48 targets

Trials18

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00974350	A Safety and Efficacy Study of SABER®-Bupivacaine for Pain Following Hernia Repair	Phase 2	124	2021-05-05	Postoperative Pain, Hernia, Surgery	BUPIVACAINE	Its record names the disease	ClinicalTrials.gov
NCT02929589	Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy	Phase 3	18	2024-03-26	Pain, Hernia	ACETAMINOPHEN, IBUPROFEN, OXYCODONE	Its record names the disease	ClinicalTrials.gov
NCT06121726	Predictive Factors for the Effectiveness of the Ilioinguinal Iliohypogastric Nerve Block for Hernia Surgery		343		Hernia Inguinal, Pain Postoperative, Regional Anesthesia	PROPOFOL	Its record names the disease	ClinicalTrials.gov
NCT02537860	Paravertebral Block for Inguinal Hernia Repair in Elderly	Not applicable	200		Inguinal Hernia Repair	BUPIVACAINE, FENTANYL	Its record names the disease	ClinicalTrials.gov
NCT05177991	Post-operative Pain Control-TAP Block Using Exparel vs. Marcaine for Hernia Repairs	Early phase 1	200		Inguinal Hernia, Ventral Hernia	BUPIVACAINE	Its record names the disease	ClinicalTrials.gov
NCT05337085	Comparison of Dexmedetomidine and Midazolam for Intra-op Sedation in TIVA in Children Undergoing Inguinal Hernia Repair	Phase 1	185		Inguinal Hernia	DEXMEDETOMIDINE, MIDAZOLAM	Its record names the disease	ClinicalTrials.gov
NCT03918798	The Efficacy and Safety of Chloroprocaine 1% and 2% in Pediatric Population	Phase 2	164		Hernia, Inguinal, Flat Foot	CHLOROPROCAINE	Its record names the disease	ClinicalTrials.gov
NCT03262688	Safety, Tolerability, PK, and Analgesic Effect of INL-001 in Children Following Open Inguinal Hernia Repair	Phase 3	159		Inguinal Hernia, Postoperative Pain	BUPIVACAINE HYDROCHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT02559102	Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants	Phase 3	104		Neurodevelopmental Disorder, Bilateral Inguinal Hernia	DEXMEDETOMIDINE, SEVOFLURANE	Its record names the disease	ClinicalTrials.gov
NCT02813382	Spinal Anesthesia for Outpatient Abdominal Wall Surgery: Comparison of Bupivacaine, 2-chloroprocaine and Prilocaine		101		Anesthesia, Spinal, Ambulatory Surgical Procedures, Hernia, Inguinal, Hernia, Umbilical	BUPIVACAINE, CHLOROPROCAINE, PRILOCAINE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 18

See all 18 trials

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials16

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
25211156	RESULT	1	PubMed
24708453	RESULT	1	PubMed
24565391	RESULT	1	PubMed
23389068	RESULT	1	PubMed
23355160	RESULT	1	PubMed
23320599	RESULT	1	PubMed
23176984	RESULT	1	PubMed
23160979	RESULT	1	PubMed
23122973	RESULT	1	PubMed
22510183	RESULT	1	PubMed

1 to 10 of 16

See all 16 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0000023

GET https://conductscience.org/api/diseases/v1/HP_0000023/targets?page=2

API reference For AI assistants