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Disease · MONDO_0004669

Targets72

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

1 to 20 of 72

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TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
ERBB2Receptor tyrosine-protein kinase erbB-26Receptor protein-tyrosine kinase erbB-2 binding agent; Receptor protein-tyrosine kinase erbB-2 inhibitorPhase 2https://conductscience.org/library/genes/2064Drugs and targets
EGFREpidermal growth factor receptor4Epidermal growth factor receptor erbB1 inhibitorPhase 2https://conductscience.org/library/genes/1956Drugs and targets
PDCD1Programmed cell death protein 14Programmed cell death protein 1 antagonist; Programmed cell death protein 1 inhibitorPhase 2https://conductscience.org/library/genes/5133Drugs and targets
TUBA1ATubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/7846Drugs and targets
TUBA1BTubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/10376Drugs and targets
TUBA1CTubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/84790Drugs and targets
TUBA3CTubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/7278Drugs and targets
TUBA3ETubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/112714Drugs and targets
TUBA4ATubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/7277Drugs and targets
TUBBTubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/203068Drugs and targets
TUBB1Tubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/81027Drugs and targets
TUBB2ATubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/7280Drugs and targets
TUBB2BTubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/347733Drugs and targets
TUBB3Tubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/10381Drugs and targets
TUBB4ATubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/10382Drugs and targets
TUBB4BTubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/10383Drugs and targets
TUBB6Tubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/84617Drugs and targets
TUBB8Tubulin4Tubulin inhibitorPhase 2https://conductscience.org/library/genes/347688Drugs and targets
ARAndrogen receptor3Androgen Receptor antagonistPhase 2https://conductscience.org/library/genes/367Drugs and targets
GNRHRGonadotropin-releasing hormone receptor3Gonadotropin-releasing hormone receptor agonistPhase 2https://conductscience.org/library/genes/2798Drugs and targets

diseases-2026-09-18-0.1.0

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Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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