Disease · MONDO_0100338
Targets17
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
1 to 17 of 17
Download this page as JSON| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| ADRA1A | Adrenergic receptor alpha-1 | 2 | Adrenergic receptor alpha-1 agonist; Adrenergic receptor alpha-1 antagonist | Phase 3 | https://conductscience.org/library/genes/148 | Drugs and targets |
| ADRA1B | Adrenergic receptor alpha-1 | 2 | Adrenergic receptor alpha-1 agonist; Adrenergic receptor alpha-1 antagonist | Phase 3 | https://conductscience.org/library/genes/147 | Drugs and targets |
| ADRA1D | Adrenergic receptor alpha-1 | 2 | Adrenergic receptor alpha-1 agonist; Adrenergic receptor alpha-1 antagonist | Phase 3 | https://conductscience.org/library/genes/146 | Drugs and targets |
| DPEP1 | Dipeptidase 1 | 2 | Renal dipeptidase inhibitor | Approval | https://conductscience.org/library/genes/1800 | Drugs and targets |
| SLC5A2 | Sodium/glucose cotransporter 2 | 2 | Sodium/glucose cotransporter 2 inhibitor | Unknown | https://conductscience.org/library/genes/6524 | Drugs and targets |
| DPP4 | Dipeptidyl peptidase 4 | 1 | Dipeptidyl peptidase IV inhibitor | Unknown | https://conductscience.org/library/genes/1803 | Drugs and targets |
| ESR1 | Estrogen receptor | 1 | Estrogen receptor alpha agonist | Unknown | https://conductscience.org/library/genes/2099 | Drugs and targets |
| NR3C1 | Glucocorticoid receptor | 1 | Glucocorticoid receptor agonist | Phase 3 | https://conductscience.org/library/genes/2908 | Drugs and targets |
| PDE4A | Phosphodiesterase 4 | 1 | Phosphodiesterase 4 inhibitor | Approval | https://conductscience.org/library/genes/5141 | Drugs and targets |
| PDE4B | Phosphodiesterase 4 | 1 | Phosphodiesterase 4 inhibitor | Approval | https://conductscience.org/library/genes/5142 | Drugs and targets |
| PDE4C | Phosphodiesterase 4 | 1 | Phosphodiesterase 4 inhibitor | Approval | https://conductscience.org/library/genes/5143 | Drugs and targets |
| PDE4D | Phosphodiesterase 4 | 1 | Phosphodiesterase 4 inhibitor | Approval | https://conductscience.org/library/genes/5144 | Drugs and targets |
| PDE7A | Phosphodiesterase 7 | 1 | Phosphodiesterase 7 inhibitor | Approval | https://conductscience.org/library/genes/5150 | Drugs and targets |
| PDE7B | Phosphodiesterase 7 | 1 | Phosphodiesterase 7 inhibitor | Approval | https://conductscience.org/library/genes/27115 | Drugs and targets |
| PDE8A | Phosphodiesterase 8 | 1 | Phosphodiesterase 8 inhibitor | Approval | https://conductscience.org/library/genes/5151 | Drugs and targets |
| PDE8B | Phosphodiesterase 8 | 1 | Phosphodiesterase 8 inhibitor | Approval | https://conductscience.org/library/genes/8622 | Drugs and targets |
| SERPINC1 | Antithrombin-III | 1 | Antithrombin-III activator | Phase 2 | https://conductscience.org/library/genes/462 | Drugs and targets |
diseases-2026-09-18-0.1.0
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
Twenty rows a page, as JSON. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0100338/targets