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Disease · MONDO_0005113

Targets78

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

1 to 20 of 78

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TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
CSF3RGranulocyte colony-stimulating factor receptor3Granulocyte colony stimulating factor receptor agonistPhase 3https://conductscience.org/library/genes/1441Drugs and targets
PTGS1Cyclooxygenase3Cyclooxygenase inhibitorUnknownhttps://conductscience.org/library/genes/5742Drugs and targets
PTGS2Cyclooxygenase3Cyclooxygenase inhibitorUnknownhttps://conductscience.org/library/genes/5743Drugs and targets
ATP4APotassium-transporting ATPase2Potassium-transporting ATPase inhibitorApprovalhttps://conductscience.org/library/genes/495Drugs and targets
ATP4BPotassium-transporting ATPase2Potassium-transporting ATPase inhibitorApprovalhttps://conductscience.org/library/genes/496Drugs and targets
TOP2ADNA topoisomerase 2-alpha2DNA topoisomerase II alpha inhibitor; DNA topoisomerase II inhibitorApprovalhttps://conductscience.org/library/genes/7153Drugs and targets
ACEAngiotensin-converting enzyme1Angiotensin-converting enzyme inhibitorUnknownhttps://conductscience.org/library/genes/1636Drugs and targets
ADRB1Beta-1 adrenergic receptor1Beta-1 adrenergic receptor antagonistUnknownhttps://conductscience.org/library/genes/153Drugs and targets
CACNA1CVoltage-gated L-type calcium channel1Voltage-gated L-type calcium channel blockerUnknownhttps://conductscience.org/library/genes/775Drugs and targets
CACNA1DVoltage-gated L-type calcium channel1Voltage-gated L-type calcium channel blockerUnknownhttps://conductscience.org/library/genes/776Drugs and targets
CACNA1FVoltage-gated L-type calcium channel1Voltage-gated L-type calcium channel blockerUnknownhttps://conductscience.org/library/genes/778Drugs and targets
CACNA1SVoltage-gated L-type calcium channel1Voltage-gated L-type calcium channel blockerUnknownhttps://conductscience.org/library/genes/779Drugs and targets
COXFA4Mitochondrial complex I (NADH dehydrogenase)1Mitochondrial complex I (NADH dehydrogenase) inhibitorPhase 2https://conductscience.org/library/genes/4697Drugs and targets
COXFA4L2Mitochondrial complex I (NADH dehydrogenase)1Mitochondrial complex I (NADH dehydrogenase) inhibitorPhase 2https://conductscience.org/library/genes/56901Drugs and targets
DLL3Delta-like protein 31Delta-like protein 3 binding agentPhase 1https://conductscience.org/library/genes/10683Drugs and targets
DPEP1Dipeptidase 11Renal dipeptidase inhibitorApprovalhttps://conductscience.org/library/genes/1800Drugs and targets
FAAHFatty-acid amide hydrolase 11Anandamide amidohydrolase inhibitorUnknownhttps://conductscience.org/library/genes/2166Drugs and targets
GPD2Glycerol-3-phosphate dehydrogenase, mitochondrial1Mitochondrial glycerol-3-phosphate dehydrogenase inhibitorPhase 2https://conductscience.org/library/genes/2820Drugs and targets
HRH2Histamine H2 receptor1Histamine H2 receptor antagonistUnknownhttps://conductscience.org/library/genes/3274Drugs and targets
MMP1Interstitial collagenase1Matrix metalloproteinase-1 inhibitorApprovalhttps://conductscience.org/library/genes/4312Drugs and targets

diseases-2026-09-18-0.1.0

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Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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