Disease · MONDO_0010481
Targets19
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
1 to 19 of 19
Download this page as JSON| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| KLKB1 | Plasma kallikrein | 4 | Plasma kallikrein inhibitor | Approval | https://conductscience.org/library/genes/3818 | Drugs and targets |
| BDKRB2 | B2 bradykinin receptor | 2 | Bradykinin B2 receptor antagonist | Approval | https://conductscience.org/library/genes/624 | Drugs and targets |
| HRH1 | Histamine H1 receptor | 2 | Histamine H1 receptor antagonist | Approval | https://conductscience.org/library/genes/3269 | Drugs and targets |
| ADRA1A | Adrenergic receptor | 1 | Adrenergic receptor agonist | Approval | https://conductscience.org/library/genes/148 | Drugs and targets |
| ADRA1B | Adrenergic receptor | 1 | Adrenergic receptor agonist | Approval | https://conductscience.org/library/genes/147 | Drugs and targets |
| ADRA1D | Adrenergic receptor | 1 | Adrenergic receptor agonist | Approval | https://conductscience.org/library/genes/146 | Drugs and targets |
| ADRA2A | Adrenergic receptor | 1 | Adrenergic receptor agonist | Approval | https://conductscience.org/library/genes/150 | Drugs and targets |
| ADRA2B | Adrenergic receptor | 1 | Adrenergic receptor agonist | Approval | https://conductscience.org/library/genes/151 | Drugs and targets |
| ADRA2C | Adrenergic receptor | 1 | Adrenergic receptor agonist | Approval | https://conductscience.org/library/genes/152 | Drugs and targets |
| ADRB1 | Adrenergic receptor | 1 | Adrenergic receptor agonist | Approval | https://conductscience.org/library/genes/153 | Drugs and targets |
| ADRB2 | Adrenergic receptor | 1 | Adrenergic receptor agonist | Approval | https://conductscience.org/library/genes/154 | Drugs and targets |
| ADRB3 | Adrenergic receptor | 1 | Adrenergic receptor agonist | Approval | https://conductscience.org/library/genes/155 | Drugs and targets |
| C1S | Complement C1s subcomponent | 1 | Complement C1s inhibitor | Phase 3 | https://conductscience.org/library/genes/716 | Drugs and targets |
| F11 | Coagulation factor XI | 1 | Coagulation factor XI inhibitor | Phase 3 | https://conductscience.org/library/genes/2160 | Drugs and targets |
| F12 | Coagulation factor XII | 1 | Coagulation factor XII inhibitor | Phase 3 | https://conductscience.org/library/genes/2161 | Drugs and targets |
| IGHE | Immunoglobulin heavy constant epsilon | 1 | Ig epsilon chain C region inhibitor | Phase 3 | https://conductscience.org/library/genes/3497 | Drugs and targets |
| PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1 | PI3-kinase p110-delta subunit inhibitor | Phase 1/2 | https://conductscience.org/library/genes/5293 | Drugs and targets |
| PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 | PI3-kinase p110-gamma subunit inhibitor | Phase 1/2 | https://conductscience.org/library/genes/5294 | Drugs and targets |
| SERPING1 | Plasma protease C1 inhibitor | 1 | Plasma protease C1 inhibitor exogenous protein | Phase 3 | https://conductscience.org/library/genes/710 | Drugs and targets |
diseases-2026-09-18-0.1.0
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
Twenty rows a page, as JSON. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0010481/targets