Disease · HP_0000713
Targets69
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
1 to 20 of 69
Download this page as JSON| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| HTR2A | 5-hydroxytryptamine receptor 2A | 15 | Serotonin 2a (5-HT2a) receptor antagonist; Serotonin 2a (5-HT2a) receptor inverse agonist | Approval | https://conductscience.org/library/genes/3356 | Drugs and targets |
| DRD2 | D(2) dopamine receptor | 14 | D2-like dopamine receptor antagonist; D2-like dopamine receptor inverse agonist; Dopamine D2 receptor antagonist; Dopamine D2 receptor partial agonist | Approval | https://conductscience.org/library/genes/1813 | Drugs and targets |
| HTR2C | 5-hydroxytryptamine receptor 2C | 9 | Serotonin 2c (5-HT2c) receptor antagonist | Approval | https://conductscience.org/library/genes/3358 | Drugs and targets |
| GABRA1 | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2554 | Drugs and targets |
| GABRA2 | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2555 | Drugs and targets |
| GABRA3 | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2556 | Drugs and targets |
| GABRA4 | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2557 | Drugs and targets |
| GABRA5 | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2558 | Drugs and targets |
| GABRA6 | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2559 | Drugs and targets |
| GABRB1 | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2560 | Drugs and targets |
| GABRB2 | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2561 | Drugs and targets |
| GABRB3 | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2562 | Drugs and targets |
| GABRD | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2563 | Drugs and targets |
| GABRE | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2564 | Drugs and targets |
| GABRG1 | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2565 | Drugs and targets |
| GABRG2 | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2566 | Drugs and targets |
| GABRG3 | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2567 | Drugs and targets |
| GABRP | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/2568 | Drugs and targets |
| GABRQ | GABA-A receptor; anion channel | 5 | GABA-A receptor; anion channel positive allosteric modulator | Approval | https://conductscience.org/library/genes/55879 | Drugs and targets |
| DRD3 | D2-like dopamine receptor | 4 | D2-like dopamine receptor antagonist; D2-like dopamine receptor inverse agonist | Approval | https://conductscience.org/library/genes/1814 | Drugs and targets |
diseases-2026-09-18-0.1.0
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
Twenty rows a page, as JSON. No key.
GET https://conductscience.org/api/diseases/v1/HP_0000713/targets