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Disease · MONDO_0004247

Targets24

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

1 to 20 of 24

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TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
ATP4APotassium-transporting ATPase12Potassium-transporting ATPase blocker; Potassium-transporting ATPase inhibitorApprovalhttps://conductscience.org/library/genes/495Drugs and targets
ATP4BPotassium-transporting ATPase12Potassium-transporting ATPase blocker; Potassium-transporting ATPase inhibitorApprovalhttps://conductscience.org/library/genes/496Drugs and targets
CHRM1Muscarinic acetylcholine receptor9Muscarinic acetylcholine receptor M1 antagonist; Muscarinic acetylcholine receptor inhibitorApprovalhttps://conductscience.org/library/genes/1128Drugs and targets
CHRM3Muscarinic acetylcholine receptor8Muscarinic acetylcholine receptor M3 antagonist; Muscarinic acetylcholine receptor inhibitorApprovalhttps://conductscience.org/library/genes/1131Drugs and targets
HRH2Histamine H2 receptor7Histamine H2 receptor antagonistApprovalhttps://conductscience.org/library/genes/3274Drugs and targets
NR3C1Glucocorticoid receptor5Glucocorticoid receptor agonistApprovalhttps://conductscience.org/library/genes/2908Drugs and targets
PTGS2Cyclooxygenase4Cyclooxygenase inhibitor; Cyclooxygenase-2 inhibitorApprovalhttps://conductscience.org/library/genes/5743Drugs and targets
CHRM2Muscarinic acetylcholine receptor3Muscarinic acetylcholine receptor M2 antagonist; Muscarinic acetylcholine receptor inhibitorApprovalhttps://conductscience.org/library/genes/1129Drugs and targets
PTGS1Cyclooxygenase3Cyclooxygenase inhibitorApprovalhttps://conductscience.org/library/genes/5742Drugs and targets
ADRB1Beta-1 adrenergic receptor1Beta-1 adrenergic receptor antagonistPhase 2/3https://conductscience.org/library/genes/153Drugs and targets
ADRB2Beta-2 adrenergic receptor1Beta-2 adrenergic receptor antagonistPhase 2/3https://conductscience.org/library/genes/154Drugs and targets
CCKARCholecystokinin receptor1Cholecystokinin receptor antagonistApprovalhttps://conductscience.org/library/genes/886Drugs and targets
CCKBRCholecystokinin receptor1Cholecystokinin receptor antagonistApprovalhttps://conductscience.org/library/genes/887Drugs and targets
CHRM4Muscarinic acetylcholine receptor1Muscarinic acetylcholine receptor inhibitorApprovalhttps://conductscience.org/library/genes/1132Drugs and targets
CHRM5Muscarinic acetylcholine receptor1Muscarinic acetylcholine receptor inhibitorApprovalhttps://conductscience.org/library/genes/1133Drugs and targets
HSD11B111-beta-hydroxysteroid dehydrogenase111-beta-hydroxysteroid dehydrogenase inhibitorApprovalhttps://conductscience.org/library/genes/3290Drugs and targets
HSD11B211-beta-hydroxysteroid dehydrogenase111-beta-hydroxysteroid dehydrogenase inhibitorApprovalhttps://conductscience.org/library/genes/3291Drugs and targets
MMP1Interstitial collagenase1Matrix metalloproteinase-1 inhibitorUnknownhttps://conductscience.org/library/genes/4312Drugs and targets
MMP13Collagenase 31Matrix metalloproteinase 13 inhibitorUnknownhttps://conductscience.org/library/genes/4322Drugs and targets
MMP7Matrilysin1Matrix metalloproteinase 7 inhibitorUnknownhttps://conductscience.org/library/genes/4316Drugs and targets

diseases-2026-09-18-0.1.0

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Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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