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Disease · MONDO_0004849

Targets23

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

1 to 20 of 23

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TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
ADRB2Beta-2 adrenergic receptor9Beta-2 adrenergic receptor agonistApprovalhttps://conductscience.org/library/genes/154Drugs and targets
CHRM3Muscarinic acetylcholine receptor M36Muscarinic acetylcholine receptor M3 antagonistApprovalhttps://conductscience.org/library/genes/1131Drugs and targets
CSF3RGranulocyte colony-stimulating factor receptor3Granulocyte colony stimulating factor receptor agonistUnknownhttps://conductscience.org/library/genes/1441Drugs and targets
NR3C1Glucocorticoid receptor3Glucocorticoid receptor agonistApprovalhttps://conductscience.org/library/genes/2908Drugs and targets
RARGRetinoic acid receptor3Retinoic acid receptor agonist; Retinoic acid receptor gamma agonistPhase 2https://conductscience.org/library/genes/5916Drugs and targets
ELANENeutrophil elastase2Leukocyte elastase inhibitorApprovalhttps://conductscience.org/library/genes/1991Drugs and targets
PDE4APhosphodiesterase 42Phosphodiesterase 4 inhibitorPhase 3https://conductscience.org/library/genes/5141Drugs and targets
PDE4BPhosphodiesterase 42Phosphodiesterase 4 inhibitorPhase 3https://conductscience.org/library/genes/5142Drugs and targets
PDE4CPhosphodiesterase 42Phosphodiesterase 4 inhibitorPhase 3https://conductscience.org/library/genes/5143Drugs and targets
PDE4DPhosphodiesterase 42Phosphodiesterase 4 inhibitorPhase 3https://conductscience.org/library/genes/5144Drugs and targets
PTGS1Cyclooxygenase2Cyclooxygenase inhibitorPhase 2https://conductscience.org/library/genes/5742Drugs and targets
PTGS2Cyclooxygenase2Cyclooxygenase inhibitorPhase 2https://conductscience.org/library/genes/5743Drugs and targets
RARARetinoic acid receptor2Retinoic acid receptor agonistPhase 2https://conductscience.org/library/genes/5914Drugs and targets
RARBRetinoic acid receptor2Retinoic acid receptor agonistPhase 2https://conductscience.org/library/genes/5915Drugs and targets
CHRM1Muscarinic acetylcholine receptor M11Muscarinic acetylcholine receptor M1 antagonistApprovalhttps://conductscience.org/library/genes/1128Drugs and targets
IMPDH1Inosine-5'-monophosphate dehydrogenase (IMPDH)1Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorPhase 3https://conductscience.org/library/genes/3614Drugs and targets
IMPDH2Inosine-5'-monophosphate dehydrogenase (IMPDH)1Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorPhase 3https://conductscience.org/library/genes/3615Drugs and targets
MMP1Interstitial collagenase1Matrix metalloproteinase-1 inhibitorPhase 2https://conductscience.org/library/genes/4312Drugs and targets
MMP13Collagenase 31Matrix metalloproteinase 13 inhibitorPhase 2https://conductscience.org/library/genes/4322Drugs and targets
MMP7Matrilysin1Matrix metalloproteinase 7 inhibitorPhase 2https://conductscience.org/library/genes/4316Drugs and targets

diseases-2026-09-18-0.1.0

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Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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